trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone

Base Information

• Chemical Name: trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone
• CAS No.: 170645-75-7
• Molecular Formula: C₁₇H₁₅NO₅
• Molecular Weight: 313.31
• Mol file: 170645-75-7.mol

Synonyms:trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone

Chemical Property of trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone

There total 3 articles about trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

chloromethyl methyl ether (107-30-2) + trans-1-(2-nitrophenyl)-3-(4-hydroxyphenyl)-2-propenone → trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone (170645-75-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1002/jlcr.2580360803

Reference yield:

2-acetylnitrobenzene (577-59-3) → trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone (170645-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / HCl / ethanol / 0.23 h

2: 76 percent / i-Pr₂NEt / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1002/jlcr.2580360803

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone (170645-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / HCl / ethanol / 0.23 h

2: 76 percent / i-Pr₂NEt / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1002/jlcr.2580360803

upstream raw materials:

chloromethyl methyl ether

2-acetylnitrobenzene

4-hydroxy-benzaldehyde