Technology Process of (2R,3R,4R,5S)-2-(5-(benzyloxy)pentyl)piperidine-3,4,5-triol
There total 8 articles about (2R,3R,4R,5S)-2-(5-(benzyloxy)pentyl)piperidine-3,4,5-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
20% palladium hydroxide-activated charcoal; hydrogen;
In
methanol;
for 12h;
DOI:10.1039/c4md00074a
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / 80 °C
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere
2.2: 15 h / -78 - 20 °C / Inert atmosphere
3.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 16 h
4.1: acetic acid / water / 1 h / 60 °C
5.1: thionyl chloride; pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere
6.1: sodium azide / N,N-dimethyl-formamide / 16 h / 105 °C / Inert atmosphere
7.1: Dowex 50WX8100 (H+) resin / water; acetonitrile / 3 h / Reflux
8.1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 12 h
With
pyridine; thionyl chloride; sodium azide; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hexamethyldisilazane; acetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c4md00074a
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium azide / N,N-dimethyl-formamide / 16 h / 105 °C / Inert atmosphere
2: Dowex 50WX8100 (H+) resin / water; acetonitrile / 3 h / Reflux
3: hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 12 h
With
sodium azide; 20% palladium hydroxide-activated charcoal; hydrogen;
In
methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c4md00074a
