N-(3-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)propyl)-2-(dimethylamino)-N-methylacetamide

Base Information

Chemical Name:N-(3-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)propyl)-2-(dimethylamino)-N-methylacetamide
CAS No.:1315464-80-2
Molecular Formula:C₂₂H₂₄F₃N₇O
Molecular Weight:459.474
Hs Code.:

Synonyms:N-(3-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)propyl)-2-(dimethylamino)-N-methylacetamide

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Chemical Property of N-(3-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)propyl)-2-(dimethylamino)-N-methylacetamide

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Technology Process of N-(3-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)propyl)-2-(dimethylamino)-N-methylacetamide

There total 7 articles about N-(3-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)propyl)-2-(dimethylamino)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1118-68-9
dimethylaminoacetic acid

: 1315465-38-3
1-methyl-6-(4-(3-(methylamino)propyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

: 1315464-80-2
N-(3-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)propyl)-2-(dimethylamino)-N-methylacetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: 944388-71-0
4-amino-6-chloro-3-nitropyridine-2-carbonitrile

: 1315464-80-2
N-(3-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)propyl)-2-(dimethylamino)-N-methylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetonitrile / 5 h / 80 °C

2: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C

3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

4: hydrogenchloride; sodium nitrite / 1-methyl-pyrrolidin-2-one; water / 12.03 h / 20 °C

5: Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 2 h / 20 °C

6: sodium tris(acetoxy)borohydride / tetrahydrofuran; methanol / 3 h / 20 °C

7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 5 h / 20 °C

With hydrogenchloride; potassium phosphate; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; potassium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1104380-98-4
6-chloro-4-(methylamino)-3-nitro-2-pyridinecarbonitrile

: 1315464-80-2
N-(3-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)propyl)-2-(dimethylamino)-N-methylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C

2: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

3: hydrogenchloride; sodium nitrite / 1-methyl-pyrrolidin-2-one; water / 12.03 h / 20 °C

4: Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 2 h / 20 °C

5: sodium tris(acetoxy)borohydride / tetrahydrofuran; methanol / 3 h / 20 °C

6: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 5 h / 20 °C

With hydrogenchloride; potassium phosphate; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;