5-bromo-5-[4-(4-bromophenoxy)phenyl]pyrimidine-2,4,6-trione

Base Information

• Chemical Name: 5-bromo-5-[4-(4-bromophenoxy)phenyl]pyrimidine-2,4,6-trione
• CAS No.: 852631-24-4
• Molecular Formula: C₁₆H₁₀Br₂N₂O₄
• Molecular Weight: 454.074
• Mol file: 852631-24-4.mol

Synonyms:5-bromo-5-[4-(4-bromophenoxy)phenyl]pyrimidine-2,4,6-trione

Chemical Property of 5-bromo-5-[4-(4-bromophenoxy)phenyl]pyrimidine-2,4,6-trione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-5-[4-(4-bromophenoxy)phenyl]pyrimidine-2,4,6-trione

There total 9 articles about 5-bromo-5-[4-(4-bromophenoxy)phenyl]pyrimidine-2,4,6-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5-[4-(4-bromophenoxy)phenyl]barbituric acid (852631-19-7) → 5-bromo-5-[4-(4-bromophenoxy)phenyl]pyrimidine-2,4,6-trione (852631-24-4)

Guidance literature:

With hydrogen bromide; bromine; at 0 - 10 ℃;

DOI:10.1021/jm049145x

Reference yield: 51.0%

4-Bromodiphenyl ether (101-55-3) + 5-diazo-pyrimidine-2,4,6-trione (31221-06-4,902267-12-3) → 5-bromo-5-[4-(4-bromophenoxy)phenyl]pyrimidine-2,4,6-trione (852631-24-4) + 5-bromo-5-(2-(4-bromophenoxy)phenyl)barbituric acid

Guidance literature:

4-Bromodiphenyl ether; 5-diazo-pyrimidine-2,4,6-trione; With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; at 120 ℃; for 16h;

With pyridinium hydrobromide perbromide; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/anie.201502324

Reference yield:

[4-(4-bromophenoxy)phenyl]acetic acid (852631-08-4) → 5-bromo-5-[4-(4-bromophenoxy)phenyl]pyrimidine-2,4,6-trione (852631-24-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / SOCl₂ / 1 h / Heating

2: 83 percent / NaH / dioxane / 3 h / Heating

3: 82 percent / NaOEt / ethanol / 6 h / Heating

4: 56 percent / aq. HBr; Br₂ / 0 - 10 °C

With thionyl chloride; hydrogen bromide; bromine; sodium ethanolate; sodium hydride; In 1,4-dioxane; ethanol;

DOI:10.1021/jm049145x

upstream raw materials:

5-[4-(4-bromophenoxy)phenyl]barbituric acid

[4-(4-bromophenoxy)phenyl]acetic acid

[4-(4-bromophenoxy)phenyl]acetic acid methyl ester

[4-(4-bromophenoxy)phenyl]malonic acid dimethyl ester

Downstream raw materials:

5-[4-(4-bromo-phenoxy)-phenyl]-5-[4-(4-trimethylsilanyl-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione

5-[4-(4-bromo-phenoxy)-phenyl]-5-piperazin-1-yl-pyrimidine-2,4,6-trione

5-[4-(4-bromo-phenoxy)-phenyl]-5-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione