1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)-3-methylbut-3-en-1-ol

Base Information

Chemical Name:1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)-3-methylbut-3-en-1-ol
CAS No.:1331836-48-6
Molecular Formula:C₁₉H₂₃NO₄S
Molecular Weight:361.462
Hs Code.:

Synonyms:1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)-3-methylbut-3-en-1-ol

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Chemical Property of 1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)-3-methylbut-3-en-1-ol

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Technology Process of 1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)-3-methylbut-3-en-1-ol

There total 2 articles about 1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)-3-methylbut-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331836-65-7
C₁₅H₁₅NO₄S

: 5674-01-1
2-methylallylmagnesium chloride

: 1331836-48-6
1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)-3-methylbut-3-en-1-ol

Guidance literature:: C₁₅H₁₅NO₄S; 2-methylallylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; at 0 - 20 ℃; Saturated solution;
DOI:10.1021/ol201510u

Reference yield:

: 1229516-61-3
3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carbaldehyde

: 1331836-48-6
1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)-3-methylbut-3-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium diacetate; caesium carbonate; triphenylphosphine / tetrahydrofuran; water / 4.5 h / 65 °C

2.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Saturated solution

With palladium diacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; water; 1.1: Suzuki-Miyaura coupling;
DOI:10.1021/ol201510u

Reference yield:

: 1331836-48-6
1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)-3-methylbut-3-en-1-ol

: C₁₇H₁₉NO₄S

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol201510u