1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea

Base Information

Chemical Name:1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea
CAS No.:1027266-81-4
Molecular Formula:C₁₈H₁₆F₂N₄O₂S
Molecular Weight:390.413
Hs Code.:

Synonyms:1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea

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Chemical Property of 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea

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Technology Process of 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea

There total 8 articles about 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 207974-17-2
2,6-difluorophenylisothiocyanate

: 99911-03-2
7,8-diamino-4,4-dimethyl-2H,4H-isoquinoline-1,3-dione

: 1027266-81-4
1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea

Guidance literature:: In ethyl acetate; at 20 ℃;
DOI:10.1021/jm020113o

Reference yield:

: 5488-36-8
4,4-dimethyl-4H-isoquinoline-1,3-dione

: 1027266-81-4
1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / H₂SO₄; HNO₃ / 0 - 5 °C

2: 98 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 2585.81 Torr

3: 86 percent / 3 h / 20 °C

4: 90percent aq. HNO₃ / -20 °C

5: 99 percent / 90percent aq. H₂SO₄ / 8 h / 70 °C

6: 100 percent / H₂ / PtO₂ / methanol / 1.25 h / 2585.81 Torr

7: ethyl acetate / 20 °C

With sulfuric acid; hydrogen; nitric acid; platinum(IV) oxide; In methanol; ethyl acetate;
DOI:10.1021/jm020113o

Reference yield:

: 14576-21-7
4,4-dimethyl-7-nitro-2H-3,4-dihydro-isoquinolin-1,3-dione

: 1027266-81-4
1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 2585.81 Torr

2: 86 percent / 3 h / 20 °C

3: 90percent aq. HNO₃ / -20 °C

4: 99 percent / 90percent aq. H₂SO₄ / 8 h / 70 °C

5: 100 percent / H₂ / PtO₂ / methanol / 1.25 h / 2585.81 Torr

6: ethyl acetate / 20 °C

With hydrogen; platinum(IV) oxide; In methanol; ethyl acetate;
DOI:10.1021/jm020113o