7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Base Information

Chemical Name:7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide
CAS No.:877165-58-7
Molecular Formula:C₂₃H₂₇N₃O₅S
Molecular Weight:457.55
Hs Code.:

Synonyms:7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Suppliers and Price of 7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

There total 11 articles about 7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 695179-07-8
N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulphonamide hydrochloride

: 1215385-15-1
7-formyl-1-methyl-1H-indole-2-carboxylic acid

: 877165-58-7
7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Guidance literature:: 7-formyl-1-methyl-1H-indole-2-carboxylic acid; With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulphonamide hydrochloride; In N,N-dimethyl-formamide; at 50 ℃; for 12h;

Reference yield:

: 1215385-55-9
7-hydroxymethyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

: 877165-58-7
7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Guidance literature:: With 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate; In dichloromethane; at 20 ℃; for 12h; Molecular sieve;

Reference yield:

: 50709-33-6
2-bromophenylhydrazine hydrochloride

: 877165-58-7
7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / toluene / 1 h

2.1: toluene-4-sulfonic acid / toluene / 16 h / Reflux; Water separator

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

3.2: 12 h / 20 °C

4.1: sodium hydroxide; methanol / 3 h / 20 °C

4.2: pH 2

5.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

5.2: 2.5 h / 20 °C

6.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 15 h / 80 °C / 1500.15 Torr

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere

8.1: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / dichloromethane / 12 h / 20 °C / Molecular sieve

With methanol; lithium aluminium tetrahydride; sodium hydride; 4-methylmorpholine N-oxide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; sodium hydroxide; tetrapropylammonium perruthennate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;