Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / chloroform / 12 h / Molecular sieve; Reflux
2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / dichloromethane; ethyl acetate / 2 h / 20 °C
4.1: potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,2-dimethoxyethane / 0.33 h / 120 °C / Irradiation
4.2: 0.22 h / 120 °C / Irradiation
With
potassium carbonate; toluene-4-sulfonic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,2-dimethoxyethane; dichloromethane; chloroform; ethyl acetate;