N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-chlorphenyl)glutaminsaeure

Base Information

Chemical Name:N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-chlorphenyl)glutaminsaeure
CAS No.:136451-06-4
Molecular Formula:C₂₆H₂₅ClN₈O₅
Molecular Weight:564.988
Hs Code.:

Synonyms:N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-chlorphenyl)glutaminsaeure

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Chemical Property of N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-chlorphenyl)glutaminsaeure

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Technology Process of N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-chlorphenyl)glutaminsaeure

There total 4 articles about N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-chlorphenyl)glutaminsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 136451-02-0
Diethyl-N-<4-<(2,4-diamino-6-pteridinyl)methyl>-N-methylaminobenzoyl>-β-(4-chlorphenyl)glutamat

: 136451-06-4
N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-chlorphenyl)glutaminsaeure

Guidance literature:: With sodium hydroxide; In ethanol; for 3h; Ambient temperature;
DOI:10.1002/ardp.2503240808

Reference yield:

: 59368-16-0
6-bromomethyl-pteridine-2,4-diamine

: 136451-06-4
N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-chlorphenyl)glutaminsaeure

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / N,N-dimethyl-acetamide / 1.) 50 to 55 deg C, 4 h 2.) 25 deg C, 17 h

2: 91 percent / N aq. NaOH / ethanol / 3 h / Ambient temperature

With sodium hydroxide; In ethanol; N,N-dimethyl acetamide;
DOI:10.1002/ardp.2503240808

Reference yield:

: 16879-69-9
4-(N-Methyl-N-tosyl)aminobenzoylchlorid

: 136451-06-4
N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-chlorphenyl)glutaminsaeure

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / KHCO₃ / CH₂Cl₂; H₂O / 12 h / Ambient temperature

2: 78 percent / N,N-dimethyl-acetamide / 1.) 50 to 55 deg C, 4 h 2.) 25 deg C, 17 h

3: 91 percent / N aq. NaOH / ethanol / 3 h / Ambient temperature

With sodium hydroxide; potassium hydrogencarbonate; In ethanol; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1002/ardp.2503240808