tert-butyl [3-(2-fluorophenyl)-1-((benzylamino)-3-oxoprop-1-en-2-yl)]sulfonylcarbamate

Base Information

• Chemical Name: tert-butyl [3-(2-fluorophenyl)-1-((benzylamino)-3-oxoprop-1-en-2-yl)]sulfonylcarbamate
• CAS No.: 1447236-85-2
• Molecular Formula: C₂₁H₂₃FN₂O₅S
• Molecular Weight: 434.488
• Mol file: 1447236-85-2.mol

Synonyms:tert-butyl [3-(2-fluorophenyl)-1-((benzylamino)-3-oxoprop-1-en-2-yl)]sulfonylcarbamate

Chemical Property of tert-butyl [3-(2-fluorophenyl)-1-((benzylamino)-3-oxoprop-1-en-2-yl)]sulfonylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [3-(2-fluorophenyl)-1-((benzylamino)-3-oxoprop-1-en-2-yl)]sulfonylcarbamate

There total 3 articles about tert-butyl [3-(2-fluorophenyl)-1-((benzylamino)-3-oxoprop-1-en-2-yl)]sulfonylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (methylsulfonyl)carbamate (147751-16-4) → tert-butyl [3-(2-fluorophenyl)-1-((benzylamino)-3-oxoprop-1-en-2-yl)]sulfonylcarbamate (1447236-85-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran-d8 / 1 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: tetrahydrofuran / 1.5 h / 22 °C / Inert atmosphere

3.1: tetrahydrofuran-d8 / 0.17 h / 22 °C / Inert atmosphere

With n-butyllithium; diisopropylamine; In tetrahydrofuran; tetrahydrofuran-d8; hexane;

DOI:10.1021/jo400976f

Reference yield:

methyl 2-fluorobenzoate (394-35-4) → tert-butyl [3-(2-fluorophenyl)-1-((benzylamino)-3-oxoprop-1-en-2-yl)]sulfonylcarbamate (1447236-85-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran-d8 / 1 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: tetrahydrofuran / 1.5 h / 22 °C / Inert atmosphere

3.1: tetrahydrofuran-d8 / 0.17 h / 22 °C / Inert atmosphere

With n-butyllithium; diisopropylamine; In tetrahydrofuran; tetrahydrofuran-d8; hexane;

DOI:10.1021/jo400976f

Reference yield:

tert-butyl [2-(2-fluorophenyl)-2-oxoethyl]sulfonylcarbamate (1447236-83-0) → tert-butyl [3-(2-fluorophenyl)-1-((benzylamino)-3-oxoprop-1-en-2-yl)]sulfonylcarbamate (1447236-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1.5 h / 22 °C / Inert atmosphere

2: tetrahydrofuran-d8 / 0.17 h / 22 °C / Inert atmosphere

In tetrahydrofuran; tetrahydrofuran-d8;

DOI:10.1021/jo400976f

upstream raw materials:

tert-butyl [2-(2-fluorophenyl)-2-oxoethyl]sulfonylcarbamate

tert-butyl (methylsulfonyl)carbamate

methyl 2-fluorobenzoate

Downstream raw materials:

tert-butyl (1-benzylquinol-4-on-3-yl)sulfonylcarbamate

N⁶,N⁶-bis(tert-Butoxycarbonyl)-5′-amino-5′-N-(tert-butoxycarbonyl)-5′-N-[(1-benzylquinol-4-on-3-yl)sulfonyl]-5′-deoxy-2′,3′-Oisopropylideneadenosine