[1-Hydroxymethyl-3,3-dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexyl]-methanol

Base Information

Chemical Name:[1-Hydroxymethyl-3,3-dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexyl]-methanol
CAS No.:177707-36-7
Molecular Formula:C₁₇H₃₂O₂Si
Molecular Weight:296.525
Hs Code.:

Synonyms:[1-Hydroxymethyl-3,3-dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexyl]-methanol

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Chemical Property of [1-Hydroxymethyl-3,3-dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexyl]-methanol

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Technology Process of [1-Hydroxymethyl-3,3-dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexyl]-methanol

There total 4 articles about [1-Hydroxymethyl-3,3-dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 177707-56-1
3,3-Dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexane-1,1-dicarboxylic acid diethyl ester

: 177707-36-7
[1-Hydroxymethyl-3,3-dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexyl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/ja9543098

Reference yield:

: 52387-40-3
5-chloro-2,2-dimethylpentanal

: 177707-36-7
[1-Hydroxymethyl-3,3-dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexyl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / TiCl₄, C₅H₅N / CCl₄; tetrahydrofuran / 0 °C

2: 96 percent / n-BuLi, CuCN / diethyl ether / -78 - 0 °C

3: 87 percent / 10percent NaI, Cs₂CO₃, 3 Angstroem MS / acetone / Heating

4: 88 percent / LAH / tetrahydrofuran / 0 °C

With pyridine; lithium aluminium tetrahydride; n-butyllithium; 3 Angstroem MS; titanium tetrachloride; caesium carbonate; sodium iodide; In tetrahydrofuran; tetrachloromethane; diethyl ether; acetone;
DOI:10.1021/ja9543098

Reference yield:

: 177707-58-3
2-(5-Chloro-2,2-dimethyl-pentylidene)-malonic acid diethyl ester

: 177707-36-7
[1-Hydroxymethyl-3,3-dimethyl-2-(4-trimethylsilanyl-but-3-ynyl)-cyclohexyl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / n-BuLi, CuCN / diethyl ether / -78 - 0 °C

2: 87 percent / 10percent NaI, Cs₂CO₃, 3 Angstroem MS / acetone / Heating

3: 88 percent / LAH / tetrahydrofuran / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; 3 Angstroem MS; caesium carbonate; sodium iodide; In tetrahydrofuran; diethyl ether; acetone;
DOI:10.1021/ja9543098