(1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

Base Information

Chemical Name:(1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester
CAS No.:1071522-56-9
Molecular Formula:C₂₈H₃₃FN₄O₇S₂
Molecular Weight:620.723
Hs Code.:

(1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

Synonyms:(1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

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Chemical Property of (1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

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Technology Process of (1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

There total 17 articles about (1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000313-20-1
(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid

: 1071522-53-6
(1S,2R,3S,4R)-3-(3-fluoro-4-methylbenzylamino)bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

: 1071522-56-9
(1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 3h;

Reference yield:

: 4533-95-3
5-nitro-2-chlorobenzenesulfonyl chloride

: 1071522-56-9
(1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium hydroxide / toluene; water; tetrahydrofuran / 2 h / -10 °C / Reflux

1.2: pH 4

2.1: ammonium hydroxide; ammonium carbonate; copper(II) sulfate / water / 72 h / 118 °C / Autoclave; Industry scale

3.1: hydrogen / 5%-palladium/activated carbon / ethanol; water / 8 h / 55 °C / Industry scale

4.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale

5.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale

6.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale

6.2: 0 °C / Industry scale

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 3 h / 25 °C

With 4-methyl-morpholine; pyridine; ammonium hydroxide; water; hydrogen; ammonium carbonate; copper(II) sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 54734-85-9
2-amino-5-nitrobenzenesulfonamide

: 1071522-56-9
(1S,2R,3S,4R)-3-{(3-fluoro-4-methylbenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 5%-palladium/activated carbon / ethanol; water / 8 h / 55 °C / Industry scale

2.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale

3.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale

4.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale

4.2: 0 °C / Industry scale

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 3 h / 25 °C

With 4-methyl-morpholine; pyridine; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;