(E)-1-tosyl-3-(3-(trimethylsilyl)prop-1-enyl)-1H-indole

Base Information

Chemical Name:(E)-1-tosyl-3-(3-(trimethylsilyl)prop-1-enyl)-1H-indole
CAS No.:1616980-01-8
Molecular Formula:C₂₁H₂₅NO₂SSi
Molecular Weight:383.587
Hs Code.:

Synonyms:(E)-1-tosyl-3-(3-(trimethylsilyl)prop-1-enyl)-1H-indole

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Chemical Property of (E)-1-tosyl-3-(3-(trimethylsilyl)prop-1-enyl)-1H-indole

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Technology Process of (E)-1-tosyl-3-(3-(trimethylsilyl)prop-1-enyl)-1H-indole

There total 2 articles about (E)-1-tosyl-3-(3-(trimethylsilyl)prop-1-enyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 16029-98-4
trimethylsilyl iodide

: 1616980-04-1
3-allyl-1-tosyl-1H-indole

: 1616980-01-8
(E)-1-tosyl-3-(3-(trimethylsilyl)prop-1-enyl)-1H-indole

Guidance literature:: With bis(trimethylsilylmethyl)(cycloocta-1,5-diene)palladium(II); bis(3,5-di-tert-butylphenyl)(tert-butyl)phosphine; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ja505446y

Reference yield:

: 16886-09-2
3-allylindole

: 98-59-9
p-toluenesulfonyl chloride

: 1616980-01-8
(E)-1-tosyl-3-(3-(trimethylsilyl)prop-1-enyl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium hydroxide / benzene; water / 0.58 h / 20 °C / Sealed tube; Inert atmosphere

2: bis(trimethylsilylmethyl)(cycloocta-1,5-diene)palladium(II); bis(3,5-di-tert-butylphenyl)(tert-butyl)phosphine; triethylamine / 1,2-dichloro-ethane / 24 h / 20 °C / Inert atmosphere

With bis(trimethylsilylmethyl)(cycloocta-1,5-diene)palladium(II); bis(3,5-di-tert-butylphenyl)(tert-butyl)phosphine; tetrabutylammomium bromide; triethylamine; sodium hydroxide; In water; 1,2-dichloro-ethane; benzene; 2: |Heck Reaction;
DOI:10.1021/ja505446y