5-methyl-1-(2-nitrobenzyl)-1H-indole

Base Information

• Chemical Name: 5-methyl-1-(2-nitrobenzyl)-1H-indole
• CAS No.: 1390637-80-5
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.299
• Mol file: 1390637-80-5.mol

Synonyms:5-methyl-1-(2-nitrobenzyl)-1H-indole

Chemical Property of 5-methyl-1-(2-nitrobenzyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-methyl-1-(2-nitrobenzyl)-1H-indole

There total 1 articles about 5-methyl-1-(2-nitrobenzyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

5-methyl-1H-indole (614-96-0) + 2-nitrophenylmethyl bromide (3958-60-9) → 5-methyl-1-(2-nitrobenzyl)-1H-indole (1390637-80-5)

Guidance literature:

5-methyl-1H-indole; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 2h; Inert atmosphere;

2-nitrophenylmethyl bromide; In dimethyl sulfoxide; mineral oil; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2018.04.019

Reference yield: 87.0%

piperidine (110-89-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 5-methyl-1-(2-nitrobenzyl)-1H-indole (1390637-80-5) → 5-methyl-1-(2-nitrobenzyl)-3-(piperidin-1-ylmethyl)-1H-indole

Guidance literature:

piperidine; formaldehyd; With acetic acid; for 0.166667h; Inert atmosphere;

5-methyl-1-(2-nitrobenzyl)-1H-indole; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2018.04.019

Reference yield:

5-methyl-1-(2-nitrobenzyl)-1H-indole (1390637-80-5) → C16H16N2 (1408793-16-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; for 12h; under 10343.2 Torr;

DOI:10.1021/ol301620z

upstream raw materials:

5-methyl-1H-indole

2-nitrophenylmethyl bromide

Downstream raw materials:

C₁₆H₁₆N₂

C₁₈H₁₈N₂O