8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

Base Information

Chemical Name:8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
CAS No.:849681-37-4
Molecular Formula:C₁₉H₂₀Cl₂N₂O₂
Molecular Weight:379.286
Hs Code.:

8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4<i>H</i>-pyrido[3,2-<i>b</i>][1,4]oxazin-3-one

Synonyms:8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

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Chemical Property of 8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

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Technology Process of 8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

There total 5 articles about 8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 5445-17-0
Methyl 2-bromopropionate

: 849681-27-2
4-(2,4-dichloro-phenyl)-2-(1-ethyl-propylamino)-pyridin-3-ol

: 849681-37-4
8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

Guidance literature:: Methyl 2-bromopropionate; 4-(2,4-dichloro-phenyl)-2-(1-ethyl-propylamino)-pyridin-3-ol; In butanone;

With toluene-4-sulfonic acid; In toluene; for 96h;
DOI:10.1016/j.tetlet.2005.01.067

Reference yield:

: 96-22-0
pentan-3-one

: 849681-37-4
8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 62 percent / NaBH₃CN / tetrahydrofuran

2.1: 70 percent / Et₃N / tetrahydrofuran

3.1: 65 percent / LDA; BrCH₂CH₂Br / tetrahydrofuran

4.1: 80 percent / Ba(OH)2*8H₂O; Pd(PPh₃)2Cl₂ / 1,2-dimethoxy-ethane; H₂O

5.1: 87 percent / KOH / ethanol

6.1: butan-2-one

6.2: 96 percent / p-TsOH*H₂O / toluene / 96 h

With bis-triphenylphosphine-palladium(II) chloride; barium dihydroxide; potassium hydroxide; sodium cyanoborohydride; ethylene dibromide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; butanone; 4.1: Suzuki coupling reaction;
DOI:10.1016/j.tetlet.2005.01.067

Reference yield:

: 849681-24-9
3-(1-ethyl-propyl)-3H-oxazolo[4,5-b]pyridin-2-one

: 849681-37-4
8-(2,4-dichloro-phenyl)-4-(1-ethyl-propyl)-2-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 65 percent / LDA; BrCH₂CH₂Br / tetrahydrofuran

2.1: 80 percent / Ba(OH)2*8H₂O; Pd(PPh₃)2Cl₂ / 1,2-dimethoxy-ethane; H₂O

3.1: 87 percent / KOH / ethanol

4.1: butan-2-one

4.2: 96 percent / p-TsOH*H₂O / toluene / 96 h

With bis-triphenylphosphine-palladium(II) chloride; barium dihydroxide; potassium hydroxide; ethylene dibromide; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; butanone; 2.1: Suzuki coupling reaction;
DOI:10.1016/j.tetlet.2005.01.067