diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,R_S)-3-p-tolylsulfinyl-2-propenyl]malonate

Base Information

• Chemical Name: diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,R_S)-3-p-tolylsulfinyl-2-propenyl]malonate
• CAS No.: 266322-02-5
• Molecular Formula: C₂₉H₄₀O₈SSi
• Molecular Weight: 576.783

Synonyms:diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,R_S)-3-p-tolylsulfinyl-2-propenyl]malonate

Chemical Property of diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,R_S)-3-p-tolylsulfinyl-2-propenyl]malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,R_S)-3-p-tolylsulfinyl-2-propenyl]malonate

There total 5 articles about diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,R_S)-3-p-tolylsulfinyl-2-propenyl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(2E,RS)-methanesulfonic acid 3-(tolyl-4-sulfinyl)-allyl ester (266322-00-3) + 2-[3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-4H-pyran-2-ylmethyl]-malonic acid diethyl ester (439078-03-2) → diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,RS)-3-p-tolylsulfinyl-2-propenyl]malonate (266322-02-5)

Guidance literature:

2-[3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-4H-pyran-2-ylmethyl]-malonic acid diethyl ester; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h;

(2E,R_S)-methanesulfonic acid 3-(tolyl-4-sulfinyl)-allyl ester; In tetrahydrofuran; at 20 ℃; for 12h; Further stages.;

DOI:10.1002/1521-3765(20020215)8:4<884::AID-CHEM884>3.0.CO;2-Q

Reference yield:

(E)-3-((R)-Toluene-4-sulfinyl)-prop-2-en-1-ol (92210-74-7) → diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,RS)-3-p-tolylsulfinyl-2-propenyl]malonate (266322-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 72 percent / tetrahydrofuran / 12 h / 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/1521-3765(20020215)8:4<884::AID-CHEM884>3.0.CO;2-Q

Reference yield:

2-(bromomethyl)-3-((tert-butyldimethylsilyl)oxy)-4H-pyran-4-one (152547-42-7) → diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,RS)-3-p-tolylsulfinyl-2-propenyl]malonate (266322-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.33 h / 20 °C

1.2: 90 percent / tetrahydrofuran / 2 h / -78 °C

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 72 percent / tetrahydrofuran / 12 h / 20 °C

With sodium hydride; In tetrahydrofuran;

DOI:10.1002/1521-3765(20020215)8:4<884::AID-CHEM884>3.0.CO;2-Q

upstream raw materials:

(2E,R_S)-methanesulfonic acid 3-(tolyl-4-sulfinyl)-allyl ester

2-[3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-4H-pyran-2-ylmethyl]-malonic acid diethyl ester

(E)-3-((R)-Toluene-4-sulfinyl)-prop-2-en-1-ol

2-(bromomethyl)-3-((tert-butyldimethylsilyl)oxy)-4H-pyran-4-one

Downstream raw materials:

diethyl (1R,5S,6R,7R,R_S)-9-tert-butyldimethylsilyloxy-6-p-tolylsulfinyl-10-oxo-11-oxatricyclo[5.3.1.0^1,5]undec-8-ene-3,3-dicarboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 266322-02-5 diethyl 2-[(3-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,R_S)-3-p-tolylsulfinyl-2-propenyl]malonate

Send

Send

Metric Ton KG G Pound L ML

Send

Send