Technology Process of (2R,8'R)-6-benzyloxy-2,5,7,8-tetramethyl-2-yl-(4,8,12-trimethyl-3,5-tridecadienyl)chroman
There total 13 articles about (2R,8'R)-6-benzyloxy-2,5,7,8-tetramethyl-2-yl-(4,8,12-trimethyl-3,5-tridecadienyl)chroman which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 88 percent / NaOMe / methanol / 3 h / 20 °C
2.1: 84 percent / p-benzoquinone; (S,S)-benzyl-2,2'-bis(oxazolyl)-1,1'-binaphthyl / palladium trifluoroacetate / CH2Cl2 / 72 h / 20 °C
3.1: 86 percent / hydrogen / PtO2*H2O / ethyl acetate / 0.5 h / 20 °C / 760 Torr
4.1: iPr2NEt; cHex2BCl / diethyl ether; hexane / 0.5 h / -78 °C
4.2: diethyl ether; hexane / 3 h / -78 °C
5.1: 560 mg / p-toluenesulfonic acid / toluene / 0.5 h / 60 °C
6.1: diethyl ether / 1 h / -78 °C
7.1: 532 mg / p-toluenesulfonic acid / toluene / 0.5 h / 60 °C
With
(S,S)-benzyl-2,2'-bis(oxazolyl)-1,1'-binaphthyl; dicyclohexylboron chloride; hydrogen; sodium methylate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; p-benzoquinone;
platinum(IV) oxide; palladium(II) trifluoroacetate;
In
methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; toluene;
1.1: Zemplen saponification / 2.1: Wacker-Heck reaction;
DOI:10.1002/chem.200600849
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 86 percent / hydrogen / PtO2*H2O / ethyl acetate / 0.5 h / 20 °C / 760 Torr
2.1: iPr2NEt; cHex2BCl / diethyl ether; hexane / 0.5 h / -78 °C
2.2: diethyl ether; hexane / 3 h / -78 °C
3.1: 560 mg / p-toluenesulfonic acid / toluene / 0.5 h / 60 °C
4.1: diethyl ether / 1 h / -78 °C
5.1: 532 mg / p-toluenesulfonic acid / toluene / 0.5 h / 60 °C
With
dicyclohexylboron chloride; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine;
platinum(IV) oxide;
In
diethyl ether; hexane; ethyl acetate; toluene;
DOI:10.1002/chem.200600849
