3-(3-(1-(2-(2-chloroethoxy)phenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

Base Information

Chemical Name:3-(3-(1-(2-(2-chloroethoxy)phenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide
CAS No.:1095006-20-4
Molecular Formula:C₂₇H₂₉ClN₄O₃
Molecular Weight:493.005
Hs Code.:

Synonyms:3-(3-(1-(2-(2-chloroethoxy)phenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

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Chemical Property of 3-(3-(1-(2-(2-chloroethoxy)phenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

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Technology Process of 3-(3-(1-(2-(2-chloroethoxy)phenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

There total 11 articles about 3-(3-(1-(2-(2-chloroethoxy)phenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095006-19-1
N-cyclopropyl-3-(3-(1-(2-hydroxyphenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

: 107-04-0
1-Bromo-2-chloroethane

: 1095006-20-4
3-(3-(1-(2-(2-chloroethoxy)phenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: With caesium carbonate; In acetonitrile; at 90 ℃; for 18h;

Reference yield:

: 1095006-13-5
1-(2-methoxyphenyl)cyclobutanecarboxamide

: 1095006-20-4
3-(3-(1-(2-(2-chloroethoxy)phenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron tribromide / dichloromethane / 3 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

3.1: bis-[(trifluoroacetoxy)iodo]benzene / water; acetonitrile / 16 h / 20 °C

3.2: pH 13

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 100 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / 20 °C

6.1: ammonium formate / 5%-palladium/activated carbon / ethanol / 1 h / 75 °C

7.1: caesium carbonate / acetonitrile / 18 h / 90 °C

With isopropylmagnesium chloride; ammonium formate; boron tribromide; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis-[(trifluoroacetoxy)iodo]benzene; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1095006-15-7
1-(2-hydroxyphenyl)cyclobutanecarboxamide

: 1095006-20-4
3-(3-(1-(2-(2-chloroethoxy)phenyl)cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2.1: bis-[(trifluoroacetoxy)iodo]benzene / water; acetonitrile / 16 h / 20 °C

2.2: pH 13

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 100 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / 20 °C

5.1: ammonium formate / 5%-palladium/activated carbon / ethanol / 1 h / 75 °C

6.1: caesium carbonate / acetonitrile / 18 h / 90 °C

With isopropylmagnesium chloride; ammonium formate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis-[(trifluoroacetoxy)iodo]benzene; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;