6-amino-7-benzyloxy-5-carboxy-8-chlorotetralin

Base Information

Chemical Name:6-amino-7-benzyloxy-5-carboxy-8-chlorotetralin
CAS No.:160582-59-2
Molecular Formula:C₁₈H₁₈ClNO₃
Molecular Weight:331.799
Hs Code.:

Synonyms:6-amino-7-benzyloxy-5-carboxy-8-chlorotetralin

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Chemical Property of 6-amino-7-benzyloxy-5-carboxy-8-chlorotetralin

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Technology Process of 6-amino-7-benzyloxy-5-carboxy-8-chlorotetralin

There total 9 articles about 6-amino-7-benzyloxy-5-carboxy-8-chlorotetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 160582-58-1
4-benzyloxy-5-chloro-6,7,8,9-tetrahydro-3H-benzo[e]indole-1,2-dione

: 160582-59-2
6-amino-7-benzyloxy-5-carboxy-8-chlorotetralin

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; at 10 ℃; for 3h;
DOI:10.1016/S0223-5234(99)00220-2

Reference yield:

: 6240-79-5
5,6,7,8-Tetrahydro-3-nitro-2-naphthol

: 160582-59-2
6-amino-7-benzyloxy-5-carboxy-8-chlorotetralin

Guidance literature:: Multi-step reaction with 6 steps

1.1: 80 percent / Cl₂ / CHCl₃ / 6 h / 20 °C

2.1: 69 percent / K₂CO₃ / Bu₄NHSO₄ / dimethylformamide / 24 h / 20 °C

3.1: 76 percent / CuCl; KBH₄ / methanol / 1 °C

4.1: aq. HCl / dimethylformamide; H₂O / 20 - 110 °C

4.2: 59 percent / NH₂OH*HCl / H₂O; dimethylformamide / 1 h / 100 °C

5.1: conc. H₂SO₄ / 60 °C

5.2: 12 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

6.1: 70 percent / aq. NaOH; 30 percent H₂O₂ / 3 h / 10 °C

With hydrogenchloride; sodium hydroxide; potassium borohydride; sulfuric acid; dihydrogen peroxide; chlorine; potassium carbonate; copper(l) chloride; tetra(n-butyl)ammonium hydrogensulfate; In methanol; chloroform; water; N,N-dimethyl-formamide; 1.1: Chlorination / 2.1: Etherification / 3.1: Reduction / 4.1: Condensation / 4.2: Condensation / 5.1: Cyclization / 5.2: Etherification / 6.1: Ring cleavage;
DOI:10.1016/S0223-5234(99)00220-2

Reference yield:

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

: 160582-59-2
6-amino-7-benzyloxy-5-carboxy-8-chlorotetralin

Guidance literature:: Multi-step reaction with 8 steps

1.1: 90 percent HNO₃ / CH₂Cl₂ / 25 h / 0 °C

1.2: 30 percent / aq. NaOH / Bu₄NHSO₄ / 4 h / Heating

2.1: 77 percent / 1 M BBr₃ / CH₂Cl₂ / 2 h / -65 - 0 °C

3.1: 80 percent / Cl₂ / CHCl₃ / 6 h / 20 °C

4.1: 69 percent / K₂CO₃ / Bu₄NHSO₄ / dimethylformamide / 24 h / 20 °C

5.1: 76 percent / CuCl; KBH₄ / methanol / 1 °C

6.1: aq. HCl / dimethylformamide; H₂O / 20 - 110 °C

6.2: 59 percent / NH₂OH*HCl / H₂O; dimethylformamide / 1 h / 100 °C

7.1: conc. H₂SO₄ / 60 °C

7.2: 12 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

8.1: 70 percent / aq. NaOH; 30 percent H₂O₂ / 3 h / 10 °C

With hydrogenchloride; sodium hydroxide; potassium borohydride; sulfuric acid; dihydrogen peroxide; nitric acid; chlorine; boron tribromide; potassium carbonate; copper(l) chloride; tetra(n-butyl)ammonium hydrogensulfate; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 1.1: Nitration / 1.2: Methylation / 2.1: demethylation / 3.1: Chlorination / 4.1: Etherification / 5.1: Reduction / 6.1: Condensation / 6.2: Condensation / 7.1: Cyclization / 7.2: Etherification / 8.1: Ring cleavage;
DOI:10.1016/S0223-5234(99)00220-2