N²-(3,4-dimethoxyphenyl)-N⁴-(2,3-dimethyl-2H-indazol-6-yl)-N⁴-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N²-(3,4-dimethoxyphenyl)-N⁴-(2,3-dimethyl-2H-indazol-6-yl)-N⁴-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
• CAS No.: 1620059-14-4
• Molecular Formula: C₂₅H₂₈N₆O₂
• Molecular Weight: 444.536

Synonyms:N²-(3,4-dimethoxyphenyl)-N⁴-(2,3-dimethyl-2H-indazol-6-yl)-N⁴-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property of N²-(3,4-dimethoxyphenyl)-N⁴-(2,3-dimethyl-2H-indazol-6-yl)-N⁴-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N²-(3,4-dimethoxyphenyl)-N⁴-(2,3-dimethyl-2H-indazol-6-yl)-N⁴-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

There total 10 articles about N²-(3,4-dimethoxyphenyl)-N⁴-(2,3-dimethyl-2H-indazol-6-yl)-N⁴-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

C17H18ClN5 (1620059-37-1) + 3,4-dimethoxyaniline (6315-89-5) → N2-(3,4-dimethoxyphenyl)-N4-(2,3-dimethyl-2H-indazol-6-yl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1620059-14-4)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.cclet.2014.06.010

Reference yield:

2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine (5466-43-3) → N2-(3,4-dimethoxyphenyl)-N4-(2,3-dimethyl-2H-indazol-6-yl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1620059-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / ethanol; tetrahydrofuran / 50 h / Reflux

2: sodium hydride / 5 h / Reflux

3: hydrogenchloride / water; ethanol / 24 h / Inert atmosphere; Reflux

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.cclet.2014.06.010

Reference yield:

methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → N2-(3,4-dimethoxyphenyl)-N4-(2,3-dimethyl-2H-indazol-6-yl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1620059-14-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 0.2 h / Microwave irradiation

2: trichlorophosphate / 2 h / 20 °C

3: sodium hydrogencarbonate / ethanol; tetrahydrofuran / 50 h / Reflux

4: sodium hydride / 5 h / Reflux

5: hydrogenchloride / water; ethanol / 24 h / Inert atmosphere; Reflux

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.cclet.2014.06.010

upstream raw materials:

methyl 2-oxocyclopentane-1-carboxylate

6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diol

2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine

ortho-ethylaniline

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