1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole

Base Information

Chemical Name:1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole
CAS No.:215807-49-1
Molecular Formula:C₁₉H₂₂N₄O₄
Molecular Weight:370.408
Hs Code.:

Synonyms:1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole

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Chemical Property of 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole

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Technology Process of 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole

There total 6 articles about 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 215807-68-4
1-(tert-Butoxycarbonylamino)-7-[hydroxy(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole

: 215807-49-1
1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4h;
DOI:10.1039/b103834f

Reference yield: 82.0%

: 215807-43-5
1-(tert-Butoxycarbonylamino)-7-[hydroxy(2-benzyloxy-3-methoxyphenyl)methyl]-1H-benzotriazole

: 215807-49-1
1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4h;
DOI:10.1055/s-1998-1878

Reference yield:

: 181707-16-4
1-(tert-Butoxycarbonylamino)-1H-benzotriazole

: 215807-49-1
1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-3-methoxyphenyl)methyl]-1H-benzotriazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: cerium(III) chloride; BuLi / tetrahydrofuran; hexane; various solvent(s) / 3.5 h / -70 - 0 °C

1.2: 78 percent / tetrahydrofuran; hexane; various solvent(s) / 16 h / -78 - 20 °C

2.1: 83 percent / HF*pyridine / CH₂Cl₂ / 48 h

3.1: 87 percent / H₂ / 5 percent Pd/C / methanol / 4 h / 20 °C

With n-butyllithium; cerium(III) chloride; hydrogen; pyridine hydrogenfluoride; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1039/b103834f