(2S,3S,4R)-3-Azido-4,5-diacetoxy-tetrahydrofuran-2-carboxylic acid methyl ester

Base Information

• Chemical Name: (2S,3S,4R)-3-Azido-4,5-diacetoxy-tetrahydrofuran-2-carboxylic acid methyl ester
• CAS No.: 93219-03-5
• Molecular Formula: C₁₀H₁₃N₃O₇
• Molecular Weight: 287.229
• Mol file: 93219-03-5.mol

Synonyms:(2S,3S,4R)-3-Azido-4,5-diacetoxy-tetrahydrofuran-2-carboxylic acid methyl ester

Chemical Property of (2S,3S,4R)-3-Azido-4,5-diacetoxy-tetrahydrofuran-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S,4R)-3-Azido-4,5-diacetoxy-tetrahydrofuran-2-carboxylic acid methyl ester

There total 1 articles about (2S,3S,4R)-3-Azido-4,5-diacetoxy-tetrahydrofuran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzoyladenine (4005-49-6) → methyl-2-O-acetyl-3-azido-1-(6-benzoylamino-9H-purin-9-yl)-1,3-dideoxy-β-D-ribofuranuronate + (2S,3S,4R)-3-Azido-4,5-diacetoxy-tetrahydrofuran-2-carboxylic acid methyl ester (93219-03-5)

Guidance literature:

With chloro-trimethyl-silane; In 1,2-dichloro-ethane; 1,1,1,3,3,3-hexamethyl-disilazane;

Reference yield:

(2S,3S,4R)-3-Azido-4,5-diacetoxy-tetrahydrofuran-2-carboxylic acid methyl ester (93219-03-5) → 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-(O-methyl-L-tyrosylamino)-β-D-ribofuranoic acid (86936-91-6,86936-92-7)

Guidance literature:

Multi-step reaction with 4 steps

2: 0.5 N NaOH / 2.) Pd-black / 1.) room temperature, 30 min, 2.) hydrogenized at 3 atm

3: 56 percent / Et₃N / tetrahydrofuran; H₂O / 24 h

4: 1.) n-butylamine, 2.) dil. HCl / 2.) Pd-black / 2.) 3 atm

With hydrogenchloride; sodium hydroxide; N-butylamine; triethylamine; palladium; In tetrahydrofuran; water;

DOI:10.1016/S0040-4039(01)91235-3

Reference yield:

(2S,3S,4R)-3-Azido-4,5-diacetoxy-tetrahydrofuran-2-carboxylic acid methyl ester (93219-03-5) → 1-(6-benzoylamino-9H-purin-9-yl)-3-(N-benzyloxycarbonyl-O-methyl-L-tyrosylamino)-1,3-dideoxy-β-D-ribofuranuronic acid (86937-07-7)

Guidance literature:

Multi-step reaction with 3 steps

2: 0.5 N NaOH / 2.) Pd-black / 1.) room temperature, 30 min, 2.) hydrogenized at 3 atm

3: 56 percent / Et₃N / tetrahydrofuran; H₂O / 24 h

With sodium hydroxide; triethylamine; palladium; In tetrahydrofuran; water;

DOI:10.1016/S0040-4039(01)91235-3

upstream raw materials:

N-benzoyladenine

Downstream raw materials:

3-amino-1-(6-benzoylamino-9H-purin-9-yl)-1,3-dideoxy-β-D-ribofuranuronic acid

1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-(O-methyl-L-tyrosylamino)-β-D-ribofuranoic acid

1-(6-benzoylamino-9H-purin-9-yl)-3-(N-benzyloxycarbonyl-O-methyl-L-tyrosylamino)-1,3-dideoxy-β-D-ribofuranuronic acid