(R)-N⁴-Benzyloxy-N¹-[(S)-(4-fluoro-phenyl)-methylcarbamoyl-methyl]-2-isobutyl-succinamide

Base Information

• Chemical Name: (R)-N⁴-Benzyloxy-N¹-[(S)-(4-fluoro-phenyl)-methylcarbamoyl-methyl]-2-isobutyl-succinamide
• CAS No.: 168158-34-7
• Molecular Formula: C₂₄H₃₀FN₃O₄
• Molecular Weight: 443.518

Synonyms:(R)-N⁴-Benzyloxy-N¹-[(S)-(4-fluoro-phenyl)-methylcarbamoyl-methyl]-2-isobutyl-succinamide

Chemical Property of (R)-N⁴-Benzyloxy-N¹-[(S)-(4-fluoro-phenyl)-methylcarbamoyl-methyl]-2-isobutyl-succinamide

Chemical Property:

Purity/Quality:

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Technology Process of (R)-N⁴-Benzyloxy-N¹-[(S)-(4-fluoro-phenyl)-methylcarbamoyl-methyl]-2-isobutyl-succinamide

There total 4 articles about (R)-N⁴-Benzyloxy-N¹-[(S)-(4-fluoro-phenyl)-methylcarbamoyl-methyl]-2-isobutyl-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-amino-2-(4-fluorophenyl)acetic acid (19883-57-9) → (R)-N4-Benzyloxy-N1-[(S)-(4-fluoro-phenyl)-methylcarbamoyl-methyl]-2-isobutyl-succinamide (168158-34-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / H₂O; dioxane / 3 h

2: 1.) ethyl chloroformate, Et₃N / 1.) THF, 5 deg C, 2.) THF, MeOH, 2 h

3: H₂ / 10percent Pd/C / methanol / 2942.03 Torr / Ambient temperature

4: (1-(3-dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

With hydrogen; chloroformic acid ethyl ester; sodium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(97)00028-X

Reference yield:

(S)-2-(((benzyloxy)carbonyl)amino)-2-(4-fluorophenyl)acetic acid (168158-39-2) → (R)-N4-Benzyloxy-N1-[(S)-(4-fluoro-phenyl)-methylcarbamoyl-methyl]-2-isobutyl-succinamide (168158-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) ethyl chloroformate, Et₃N / 1.) THF, 5 deg C, 2.) THF, MeOH, 2 h

2: H₂ / 10percent Pd/C / methanol / 2942.03 Torr / Ambient temperature

3: (1-(3-dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

With hydrogen; chloroformic acid ethyl ester; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(97)00028-X

Reference yield:

N-benzyloxycarbonyl-L-(p-fluorophenyl)glycine-N-methylamide → (R)-N4-Benzyloxy-N1-[(S)-(4-fluoro-phenyl)-methylcarbamoyl-methyl]-2-isobutyl-succinamide (168158-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 2942.03 Torr / Ambient temperature

2: (1-(3-dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(97)00028-X

upstream raw materials:

(S)-2-Amino-2-(4-fluoro-phenyl)-N-methyl-acetamide

(S)-2-amino-2-(4-fluorophenyl)acetic acid

(S)-2-(((benzyloxy)carbonyl)amino)-2-(4-fluorophenyl)acetic acid

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