methyl 1-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-cyclopropane carboxylate

Base Information

Chemical Name:methyl 1-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-cyclopropane carboxylate
CAS No.:1383000-43-8
Molecular Formula:C₂₇H₃₂F₃N₃O₄Si
Molecular Weight:547.649
Hs Code.:

Synonyms:methyl 1-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-cyclopropane carboxylate

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Chemical Property of methyl 1-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-cyclopropane carboxylate

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Technology Process of methyl 1-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-cyclopropane carboxylate

There total 4 articles about methyl 1-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-cyclopropane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383000-42-7
methyl 1-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]cyclopropane carboxylate

: 1382998-88-0
2-bromo-5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole-2-yl]pyridine

: 1383000-43-8
methyl 1-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-cyclopropane carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1383000-43-8
methyl 1-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-cyclopropane carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate / water / 0.5 h / 95 °C

1.2: 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 20 °C / Cooling with ice

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

With sodium acetate; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1383001-87-3
2-bromo-5-[5-(trifluoromethyl)-1H-imidazole-2-yl]pyridine

: 1383000-43-8
methyl 1-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-cyclopropane carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

1.2: 20 °C / Cooling with ice

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

With sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;