N-(benzo[d][1,3]dioxol-5-yl)-4-(4-chlorophenyl)thiazol-2-amine hydrobromide

Base Information

• Chemical Name: N-(benzo[d][1,3]dioxol-5-yl)-4-(4-chlorophenyl)thiazol-2-amine hydrobromide
• CAS No.: 469891-25-6
• Molecular Formula: BrH*C₁₆H₁₁ClN₂O₂S
• Molecular Weight: 411.706
• Mol file: 469891-25-6.mol

Synonyms:N-(benzo[d][1,3]dioxol-5-yl)-4-(4-chlorophenyl)thiazol-2-amine hydrobromide

Chemical Property of N-(benzo[d][1,3]dioxol-5-yl)-4-(4-chlorophenyl)thiazol-2-amine hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(benzo[d][1,3]dioxol-5-yl)-4-(4-chlorophenyl)thiazol-2-amine hydrobromide

There total 3 articles about N-(benzo[d][1,3]dioxol-5-yl)-4-(4-chlorophenyl)thiazol-2-amine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-(benzo[d][1,3]dioxol-5-yl)thiourea (65069-55-8) + 4-chlorobenzoylmethyl bromide (536-38-9) → N-(benzo[d][1,3]dioxol-5-yl)-4-(4-chlorophenyl)thiazol-2-amine hydrobromide (469891-25-6)

Guidance literature:

In ethanol; at 80 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.07.025

Reference yield:

N-(benzo[d][1,3]dioxol-5-ylcarbamothioyl)benzamide (67618-23-9) → N-(benzo[d][1,3]dioxol-5-yl)-4-(4-chlorophenyl)thiazol-2-amine hydrobromide (469891-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 1 h / 100 °C

2: ethanol / 0.5 h / 80 °C / Microwave irradiation

With sodium hydroxide; In ethanol; water; 2: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.ejmech.2014.07.025

Reference yield:

para-chloroacetophenone (99-91-2) → N-(benzo[d][1,3]dioxol-5-yl)-4-(4-chlorophenyl)thiazol-2-amine hydrobromide (469891-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / chloroform / 2 h / 0 - 20 °C

2: ethanol / 0.5 h / 80 °C / Microwave irradiation

With bromine; In ethanol; chloroform; 2: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.ejmech.2014.07.025 DOI:10.1016/j.bmc.2014.07.044

upstream raw materials:

N-(benzo[d][1,3]dioxol-5-ylcarbamothioyl)benzamide

1-(benzo[d][1,3]dioxol-5-yl)thiourea

4-chlorobenzoylmethyl bromide

para-chloroacetophenone