2-Bromo-5-cyclopropylthiophene

Base Information

• Chemical Name: 2-Bromo-5-cyclopropylthiophene
• CAS No.: 29481-27-4
• Molecular Formula: C₇H₇BrS
• Molecular Weight: 203.103
• Hs Code.: 2934999090
• European Community (EC) Number: 816-444-0
• DSSTox Substance ID: DTXSID601306455
• Mol file: 29481-27-4.mol

Synonyms:2-bromo-5-cyclopropylthiophene;29481-27-4;2-Bromo-5-(cyclopropyl)thiophene;5-bromo-2-cyclopropylthiophene;SCHEMBL14480813;DTXSID601306455;AKOS015943499;CS-0223251;EN300-114465

Chemical Property of 2-Bromo-5-cyclopropylthiophene

Chemical Property:

• Boiling Point: 95-97 °C(Press: 10 Torr)
• Density: 1.650±0.06 g/cm3(Predicted)
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 201.94518
• Heavy Atom Count: 9
• Complexity: 112

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-cyclopropylthiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC1C2=CC=C(S2)Br

Technology Process of 2-Bromo-5-cyclopropylthiophene

There total 2 articles about 2-Bromo-5-cyclopropylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-cyclopropyl-thiophene (29481-22-9) → 5-cyclopropyl-2-bromothiophene (29481-27-4)

Guidance literature:

With N-Bromosuccinimide;

DOI:10.1007/BF00764665

Reference yield:

→ 5-cyclopropyl-2-bromothiophene (29481-27-4)

Guidance literature:

Aus 2-Cyclopropylthiophen u. N-Bromsuccinimid;

DOI:10.1021/jo00815a008

Reference yield: 71.7%

5-cyclopropyl-2-bromothiophene (29481-27-4) + (5-fluoro-2-formylphenyl)boronic acid (1256355-30-2) → 2-(5-cyclopropylthiophen-2-yl)-4-fluorobenzaldehyde

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 1.08333h; Inert atmosphere;

upstream raw materials:

2-cyclopropyl-thiophene