(+)-(1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]propane-1,2-diol

Base Information

Chemical Name:(+)-(1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]propane-1,2-diol
CAS No.:901125-37-9
Molecular Formula:C₄₄H₄₂O₈
Molecular Weight:698.813
Hs Code.:

Synonyms:(+)-(1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]propane-1,2-diol

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Chemical Property of (+)-(1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]propane-1,2-diol

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Technology Process of (+)-(1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]propane-1,2-diol

There total 7 articles about (+)-(1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,2S)-3-[2,4-Bis-benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(3,5-bis-benzyloxy-4-methoxy-phenyl)-propane-1,2-diol

: 901125-37-9
(+)-(1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]propane-1,2-diol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2006.04.010

Reference yield:

: 901125-35-7
(E)-3,5-bis(benzyloxy)-4-methoxycinnamyl alcohol

: 901125-37-9
(+)-(1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]propane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 45.1 percent / H₂SO₄/SiO₂ / CH₂Cl₂ / 20 °C

2: imidazole / dimethylformamide / 20 °C

3: AD-mix α; methanesulfonamide / CH2Cl2; 2-methyl-propan-2-ol; H2O / 0 °C

4: 2.2 g / TBAF / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; AD-mix-α; methanesulfonamide; sulfuric acid; tetrabutyl ammonium fluoride; silica gel; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.tet.2006.04.010

Reference yield:

: 901125-34-6
ethyl (E)-3,5-bis(benzyloxy)-4-methoxycinnamate

: 901125-37-9
(+)-(1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]propane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / DIBAL / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2: 45.1 percent / H₂SO₄/SiO₂ / CH₂Cl₂ / 20 °C

3: imidazole / dimethylformamide / 20 °C

4: AD-mix α; methanesulfonamide / CH2Cl2; 2-methyl-propan-2-ol; H2O / 0 °C

5: 2.2 g / TBAF / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; AD-mix-α; methanesulfonamide; sulfuric acid; tetrabutyl ammonium fluoride; silica gel; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.tet.2006.04.010