Technology Process of (1S,2R,3S,4R)-4-aminocyclopentane-1,2,3-triyl tribenzoate hydrochloride
There total 4 articles about (1S,2R,3S,4R)-4-aminocyclopentane-1,2,3-triyl tribenzoate hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 0 - 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.3762/bjoc.10.135
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere
1.2: 24 h / 50 °C / Inert atmosphere
2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 1 h / 20 °C / Inert atmosphere
3.1: pyridine / 24 h / 0 - 20 °C / Inert atmosphere
4.1: hydrogenchloride / 1,4-dioxane / 16 h / 0 - 20 °C / Inert atmosphere
With
pyridine; hydrogenchloride; osmium(VIII) oxide; sodium hydride; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; 1,4-dioxane; water; acetone; mineral oil;
1.1: |Tsuji-Trost Allylation / 1.2: |Tsuji-Trost Allylation / 2.1: |Upjohn Dihydroxylation;
DOI:10.3762/bjoc.10.135
- Guidance literature:
-
Multi-step reaction with 3 steps
1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 1 h / 20 °C / Inert atmosphere
2: pyridine / 24 h / 0 - 20 °C / Inert atmosphere
3: hydrogenchloride / 1,4-dioxane / 16 h / 0 - 20 °C / Inert atmosphere
With
pyridine; hydrogenchloride; osmium(VIII) oxide; 4-methylmorpholine N-oxide;
In
1,4-dioxane; water; acetone;
1: |Upjohn Dihydroxylation;
DOI:10.3762/bjoc.10.135
