N-(2,2-diphenylhexa-4,5-dien-1-yl)-4-methylbenzene sulfonamide

Base Information

• Chemical Name: N-(2,2-diphenylhexa-4,5-dien-1-yl)-4-methylbenzene sulfonamide
• CAS No.: 947241-17-0
• Molecular Formula: C₂₅H₂₅NO₂S
• Molecular Weight: 403.545
• Mol file: 947241-17-0.mol

Synonyms:N-(2,2-diphenylhexa-4,5-dien-1-yl)-4-methylbenzene sulfonamide

Chemical Property of N-(2,2-diphenylhexa-4,5-dien-1-yl)-4-methylbenzene sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,2-diphenylhexa-4,5-dien-1-yl)-4-methylbenzene sulfonamide

There total 2 articles about N-(2,2-diphenylhexa-4,5-dien-1-yl)-4-methylbenzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2-diphenylhexa-4,5-dien-1-amine (906542-80-1) + p-toluenesulfonyl chloride (98-59-9) → N-(2,2-diphenylhexa-4,5-dien-1-yl)-4-methylbenzene sulfonamide (947241-17-0)

Guidance literature:

With triethylamine; In dichloromethane; for 4h;

DOI:10.1002/chem.201200547

Reference yield:

2,2-diphenyl-4,5-hexadienenitrile (906542-79-8) → N-(2,2-diphenylhexa-4,5-dien-1-yl)-4-methylbenzene sulfonamide (947241-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / diethyl ether; toluene / 3.5 h / -42 °C / Reflux

1.2: 0.5 h / pH 2

2.1: triethylamine / dichloromethane / 4 h

With diisobutylaluminium hydride; triethylamine; In diethyl ether; dichloromethane; toluene;

DOI:10.1002/chem.201200547

Reference yield: 78.0%

copper(II) 2-ethylhexanoate + N-(2,2-diphenylhexa-4,5-dien-1-yl)-4-methylbenzene sulfonamide (947241-17-0) → 1-(4,4-diphenyl-1-tosylpyrrolidin-2-yl)vinyl 2-ethylhexanoate

Guidance literature:

With potassium tert-butylate; In toluene; at 105 ℃; for 2h; Reagent/catalyst; Inert atmosphere; Molecular sieve; Sealed tube;

DOI:10.1021/acs.orglett.5b02833

upstream raw materials:

2,2-diphenylhexa-4,5-dien-1-amine

p-toluenesulfonyl chloride

2,2-diphenyl-4,5-hexadienenitrile

Downstream raw materials:

C₂₅H₂₅NO₂S

4,4-diphenyl-1-p-toluene-sulfonyl-2-vinylpyrrolidine