1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Base Information

Chemical Name:1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea
CAS No.:1020172-12-6
Molecular Formula:C₂₈H₂₇FN₈O₃
Molecular Weight:542.573
Hs Code.:

Synonyms:1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Suppliers and Price of 1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

There total 6 articles about 1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 757251-39-1
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

: 1020173-49-2
tert-butyl 5-(3-tert-butyl-5-((prop-1-en-2-yloxy)carbonylamino)-1H-pyrazol-1-yl)-1H-indazole-1-carboxylate

: 1020172-12-6
1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Guidance literature:: 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide; tert-butyl 5-(3-tert-butyl-5-((prop-1-en-2-yloxy)carbonylamino)-1H-pyrazol-1-yl)-1H-indazole-1-carboxylate; With 1-Methylpyrrolidine; In tetrahydrofuran; at 55 ℃;

With hydrogenchloride; In methanol; ethyl acetate; at 20 - 55 ℃;

With sodium hydrogencarbonate; In methanol; ethyl acetate;

Reference yield:

: C₃₃H₃₅FN₈O₅

: 1020172-12-6
1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Guidance literature:: C₃₃H₃₅FN₈O₅; With hydrogenchloride; In methanol; ethyl acetate; at 55 ℃; for 3h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1020172-12-6
1-(3-tert-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 100 °C / Inert atmosphere

2.1: 1-Methylpyrrolidine / tetrahydrofuran / 55 °C

2.2: 20 - 55 °C

With 1-Methylpyrrolidine; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl acetamide;