3-(4-hydroxy-2,6-dimethoxyphenyl)-1-[4-(4-methoxybenzyloxy)phenyl]-1-propanone

Base Information

Chemical Name:3-(4-hydroxy-2,6-dimethoxyphenyl)-1-[4-(4-methoxybenzyloxy)phenyl]-1-propanone
CAS No.:1413765-67-9
Molecular Formula:C₂₅H₂₆O₆
Molecular Weight:422.478
Hs Code.:

Synonyms:3-(4-hydroxy-2,6-dimethoxyphenyl)-1-[4-(4-methoxybenzyloxy)phenyl]-1-propanone

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Chemical Property of 3-(4-hydroxy-2,6-dimethoxyphenyl)-1-[4-(4-methoxybenzyloxy)phenyl]-1-propanone

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Technology Process of 3-(4-hydroxy-2,6-dimethoxyphenyl)-1-[4-(4-methoxybenzyloxy)phenyl]-1-propanone

There total 4 articles about 3-(4-hydroxy-2,6-dimethoxyphenyl)-1-[4-(4-methoxybenzyloxy)phenyl]-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1413765-63-5
4-hydroxy-4’-(4-methoxybenzyloxy)-2,6-dimethoxychalcone

: 1413765-67-9
3-(4-hydroxy-2,6-dimethoxyphenyl)-1-[4-(4-methoxybenzyloxy)phenyl]-1-propanone

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1021/ol302858r

Reference yield:

: 72293-97-1
1-[4-[(4-methoxyphenyl)-methoxy]phenyl]ethanone

: 1413765-67-9
3-(4-hydroxy-2,6-dimethoxyphenyl)-1-[4-(4-methoxybenzyloxy)phenyl]-1-propanone

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 20 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: |Mukaiyama Aldol Addition;
DOI:10.1021/ol302858r

Reference yield:

: 99-93-4
4-Hydroxyacetophenone

: 1413765-67-9
3-(4-hydroxy-2,6-dimethoxyphenyl)-1-[4-(4-methoxybenzyloxy)phenyl]-1-propanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 15 h / 20 - 56 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 - 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 20 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetone; 2: |Mukaiyama Aldol Addition;
DOI:10.1021/ol302858r