N--N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide

Base Information

Chemical Name:N--N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide
CAS No.:167867-37-0
Molecular Formula:C₂₈H₄₅N₃O₅S
Molecular Weight:535.748
Hs Code.:

N-<N-(tert-Butoxycarbonyl)-2(S)-benzyltauryl>-N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide

Synonyms:N--N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide

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Chemical Property of N--N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide

Chemical Property:

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Technology Process of N--N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide

There total 9 articles about N--N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: [(S)-1-Benzyl-2-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinoline-2-sulfinyl)-ethyl]-carbamic acid tert-butyl ester

: 167867-37-0
N--N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide

Guidance literature:: With ruthenium trichloride; sodium periodate;
DOI:10.1021/jo00121a038

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 167867-37-0
N--N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

2: Et₃N

3: NaBH₄ / methanol

4: 96 percent / Et₃N

5: 93 percent / Cs₂CO₃ / dimethylformamide / Ambient temperature

6: Ac₂O, Cl₂ / CH₂Cl₂ / 1 h / -18 - -10 °C

7: 76 percent / N-methylmorpholine / CH₂Cl₂ / Ambient temperature

8: 98 percent / NaIO₄, aq. RuCl₃

With 4-methyl-morpholine; ruthenium trichloride; sodium tetrahydroborate; sodium periodate; acetic anhydride; chlorine; caesium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a038

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 167867-37-0
N--N'-tert-butyl-(4aS,8aS)-decahydro-3(S)-isoquinolinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

2: Et₃N

3: NaBH₄ / methanol

4: 96 percent / Et₃N

5: 93 percent / Cs₂CO₃ / dimethylformamide / Ambient temperature

6: Ac₂O, Cl₂ / CH₂Cl₂ / 1 h / -18 - -10 °C

7: 76 percent / N-methylmorpholine / CH₂Cl₂ / Ambient temperature

8: 98 percent / NaIO₄, aq. RuCl₃

With 4-methyl-morpholine; ruthenium trichloride; sodium tetrahydroborate; sodium periodate; acetic anhydride; chlorine; caesium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a038