tert-butyl (E)-4-(N-(2-ethoxy-2-oxoethyl)-2-nitrophenylsulfonamido)-3-methylbut-2-enoate

Base Information

Chemical Name:tert-butyl (E)-4-(N-(2-ethoxy-2-oxoethyl)-2-nitrophenylsulfonamido)-3-methylbut-2-enoate
CAS No.:1393090-62-4
Molecular Formula:C₁₉H₂₆N₂O₈S
Molecular Weight:442.49
Hs Code.:

Synonyms:tert-butyl (E)-4-(N-(2-ethoxy-2-oxoethyl)-2-nitrophenylsulfonamido)-3-methylbut-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (E)-4-(N-(2-ethoxy-2-oxoethyl)-2-nitrophenylsulfonamido)-3-methylbut-2-enoate

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Technology Process of tert-butyl (E)-4-(N-(2-ethoxy-2-oxoethyl)-2-nitrophenylsulfonamido)-3-methylbut-2-enoate

There total 2 articles about tert-butyl (E)-4-(N-(2-ethoxy-2-oxoethyl)-2-nitrophenylsulfonamido)-3-methylbut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 313497-39-1
2-nitrobenzenesulfonyl glycine ethyl ester

: 1393090-60-2
(E)-tert-butyl 4-hydroxy-3-methylbut-2-enoate

: 1393090-62-4
tert-butyl (E)-4-(N-(2-ethoxy-2-oxoethyl)-2-nitrophenylsulfonamido)-3-methylbut-2-enoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 25 ℃; for 2.08333h; Inert atmosphere;
DOI:10.1016/j.tet.2012.06.066

Reference yield:

: 86302-43-4,35000-38-5
(tert-Butoxycarbonylmethylene)triphenylphosphorane

: 1393090-62-4
tert-butyl (E)-4-(N-(2-ethoxy-2-oxoethyl)-2-nitrophenylsulfonamido)-3-methylbut-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 3 h / Inert atmosphere; Reflux

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.08 h / 0 - 25 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; acetonitrile; 1: Wittig reaction / 2: Mitsunobu reaction;
DOI:10.1016/j.tet.2012.06.066