tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate
• CAS No.: 1365037-83-7
• Molecular Formula: C₂₇H₂₉Cl₃N₄O₃
• Molecular Weight: 563.911
• Mol file: 1365037-83-7.mol

Synonyms:tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

Chemical Property of tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) + rimonabant acid (162758-35-2) → tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate (1365037-83-7)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; for 16h; Inert atmosphere;

DOI:10.1021/jm201731z

Reference yield:

rimonabant acid (162758-35-2) → tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate (1365037-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 3 h / Reflux

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane; toluene;

DOI:10.1021/jm4005219

Reference yield: 95.0%

tert-butyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate (1365037-83-7) → 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide (1365037-86-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 16h; Inert atmosphere;

DOI:10.1021/jm201731z

upstream raw materials:

1-(tert-butoxycarbonyl)-4-aminopiperidine

rimonabant acid

Downstream raw materials:

N-(1-acetylpiperidin-4-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1-methanesulfonylpiperidin-4-yl)-4-methyl-1H-pyrazole-3-carboxamide

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-sulfamoylpiperidin-4-yl)-1H-pyrazole-3-carboxamide

1-N-tert-butyl-4-C-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-piperidine-1,4-diamido