ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

Base Information

Chemical Name:ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate
CAS No.:1019925-07-5
Molecular Formula:C₂₈H₃₅ClN₄O₆
Molecular Weight:559.062
Hs Code.:

Synonyms:ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

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Chemical Property of ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

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Technology Process of ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

There total 2 articles about ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 710335-28-7
4-((S)-2-amino-4-tert-butoxycarbonyl-butyryl)piperazine-1-carboxylic acid ethyl ester

: 85814-96-6
4-chloro-6-phenylpyridine-2-carboxylic acid

: 1019925-07-5
ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 16h;
DOI:10.1021/jm901518t

Reference yield:

: 1019925-07-5
ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

Guidance literature:

Reference yield:

: 1019925-07-5
ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

: 107-19-7
propargyl alcohol

: 1019928-30-3
4-((S)-4-tert-butoxycarbonyl-2-{[4-(3-hydroxy-prop-1-ynyl)-6-phenyl-pyridine-2-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 36h;