2-cyclobutyl-1-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol

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Chemical Name:2-cyclobutyl-1-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol
CAS No.:1312017-08-5
Molecular Formula:C₂₁H₂₁F₃N₂O₃S
Molecular Weight:438.471
Hs Code.:

Synonyms:2-cyclobutyl-1-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol

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Chemical Property of 2-cyclobutyl-1-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol

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Technology Process of 2-cyclobutyl-1-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol

There total 7 articles about 2-cyclobutyl-1-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1312019-48-9
2-cyclobutyl-1-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol

: 1312017-08-5
2-cyclobutyl-1-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol

Guidance literature:: 2-cyclobutyl-1-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol; With sodium periodate; In methanol; water; at 25 ℃; for 16h;

With potassium permanganate; In methanol; water; at 25 ℃; for 10h;

Reference yield:

: 17247-58-4
(Bromomethyl)cyclobutane

: 1312017-08-5
2-cyclobutyl-1-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / tetrahydrofuran / 0.5 h / Reflux

2.1: tetrahydrofuran / 1 h / 0 °C

3.1: sodium periodate / water; methanol / 16 h / 25 °C

3.2: 10 h / 25 °C

With sodium periodate; iodine; magnesium; In tetrahydrofuran; methanol; water;

Reference yield:

: 123245-94-3
(cyclobutylmethyl)magnesium bromide

: 1312017-08-5
2-cyclobutyl-1-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 1 h / 0 °C

2.1: sodium periodate / water; methanol / 16 h / 25 °C

2.2: 10 h / 25 °C

With sodium periodate; In tetrahydrofuran; methanol; water;