4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol

Base Information

• Chemical Name: 4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol
• CAS No.: 944344-37-0
• Molecular Formula: C₁₄H₂₁Cl₂N₃O
• Molecular Weight: 318.246
• Mol file: 944344-37-0.mol

Synonyms:4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol

Chemical Property of 4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol

There total 2 articles about 4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)isoindoline-1,3-dione (944344-35-8) → 4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol (944344-37-0)

Guidance literature:

With hydrazine; In ethanol; for 3h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.5b00776

Reference yield:

1-(2,3-dichlorophenyl)piperazine (41202-77-1) → 4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol (944344-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Reflux

2: hydrazine / ethanol / 3 h / Reflux

With hydrazine; In ethanol;

DOI:10.1021/jm200288r

Reference yield: 78.0%

4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol (944344-37-0) + 5-iodobenzo[b]furan-2-carboxylic acid (1144854-04-5) → N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)-5-iodobenzofuran-2-carboxamide (1092953-71-3)

Guidance literature:

5-iodobenzo[b]furan-2-carboxylic acid; With thionyl chloride; for 3h; Reflux;

4-amino-1-(4-(2,3-dichlorophenyl)piperazine-1-yl)butane-2-ol; With sodium hydroxide; In chloroform; water; at 0 - 20 ℃;

DOI:10.1021/jm900095y

upstream raw materials:

2-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)isoindoline-1,3-dione

1-(2,3-dichlorophenyl)piperazine

Downstream raw materials:

N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)-4-pyridin-2-yl-benzamide

N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)-5-iodobenzofuran-2-carboxamide

N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)-1H-indole-2-carboxamide

N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)benzofuran-2-carboxamide