trans-1-ethyl-3-[9-[6-hydroxymethyl-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]urea

Base Information

• Chemical Name: trans-1-ethyl-3-[9-[6-hydroxymethyl-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]urea
• CAS No.: 911198-04-4
• Molecular Formula: C₂₂H₂₄N₆O₅
• Molecular Weight: 452.47

Synonyms:trans-1-ethyl-3-[9-[6-hydroxymethyl-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]urea

Chemical Property of trans-1-ethyl-3-[9-[6-hydroxymethyl-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]urea

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Technology Process of trans-1-ethyl-3-[9-[6-hydroxymethyl-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]urea

There total 1 articles about trans-1-ethyl-3-[9-[6-hydroxymethyl-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-1-{9-[6-(tert-butyldimethylsilanyloxymethyl)-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-3-ethylurea → trans-1-ethyl-3-[9-[6-hydroxymethyl-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]urea (911198-04-4)

Guidance literature:

trans-1-{9-[6-(tert-butyldimethylsilanyloxymethyl)-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-3-ethylurea; With tetrabutyl ammonium fluoride; In tetrahydrofuran;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield: 95.5%

trans-1-ethyl-3-[9-[6-hydroxymethyl-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]urea (911198-04-4) + p-toluenesulfonyl chloride (98-59-9) → ((2S,3aS,4R,6R,6aS)-6-(6-(3-etylureido)-9H-purin-9-yl)-2-styryl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate (1024676-67-2)

Guidance literature:

With pyridine; at 0 ℃; for 12h;

DOI:10.1016/j.bmcl.2008.01.038

Reference yield: 83.0%

trans-1-ethyl-3-[9-[6-hydroxymethyl-2-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]urea (911198-04-4) → (2S,3aS,4S,6R,6aS)-6-(6-(3-ethylureido)-9H-purin-9-yl)-2-styryltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxylic acid

Guidance literature:

With iodobenzene diacetic acid; In water; acetonitrile; at 20 ℃; for 3h;

Downstream raw materials:

4-((((2S,3aS,4R,6R,6aS)-6-(6-(3-ethylureido)-9H-purin-9-yl)-2-styryltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzoic acid

3-(((2S,3aS,4R,6R,6aS)-6-(6-(3-ethylureido)-9H-purin-9-yl)-2-styryltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)acetic acid

((2S,3aS,4R,6R,6aS)-6-(6-(3-etylureido)-9H-purin-9-yl)-2-styryl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate

3-((((2S,3aS,4R,6R,6aS)-6-(6-(3-ethylureido)-9H-purin-9-yl)-2-styryltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzoic acid

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