5-(2-bromoacetamido)-N-butyl-2-(p-trifluoromethylphenoxy)benzamide

Base Information

• Chemical Name: 5-(2-bromoacetamido)-N-butyl-2-(p-trifluoromethylphenoxy)benzamide
• CAS No.: 1395396-60-7
• Molecular Formula: C₂₀H₂₀BrF₃N₂O₃
• Molecular Weight: 473.29
• Mol file: 1395396-60-7.mol

Synonyms:5-(2-bromoacetamido)-N-butyl-2-(p-trifluoromethylphenoxy)benzamide

Chemical Property of 5-(2-bromoacetamido)-N-butyl-2-(p-trifluoromethylphenoxy)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-bromoacetamido)-N-butyl-2-(p-trifluoromethylphenoxy)benzamide

There total 6 articles about 5-(2-bromoacetamido)-N-butyl-2-(p-trifluoromethylphenoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-amino-N-butyl-2-p-trifluoromethylphenoxybenzamide (1395396-31-2) + 2-Bromoacetyl bromide (598-21-0) → 5-(2-bromoacetamido)-N-butyl-2-(p-trifluoromethylphenoxy)benzamide (1395396-60-7)

Guidance literature:

With triethylamine; In dichloromethane; water; at -10 - 20 ℃; for 3h;

DOI:10.1016/j.bmc.2012.06.026

Reference yield:

4-hydroxybenzotrifluoride (402-45-9) → 5-(2-bromoacetamido)-N-butyl-2-(p-trifluoromethylphenoxy)benzamide (1395396-60-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 2 h / 70 °C / Cooling with ice; Inert atmosphere

1.2: 4 h / 70 °C / Inert atmosphere

2.1: sodium tetrahydroborate; palladium 10% on activated carbon / methanol; water / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane; water / 3 h / -10 - 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; sodium hydride; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; mineral oil;

DOI:10.1016/j.bmc.2012.06.026

Reference yield:

N-butyl-2-p-trifluoromethylphenoxy-5-nitrobenzamide (1395396-12-9) → 5-(2-bromoacetamido)-N-butyl-2-(p-trifluoromethylphenoxy)benzamide (1395396-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; palladium 10% on activated carbon / methanol; water / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane; water / 3 h / -10 - 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; triethylamine; In methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.06.026

upstream raw materials:

N-butyl-2-p-trifluoromethylphenoxy-5-nitrobenzamide

5-amino-N-butyl-2-p-trifluoromethylphenoxybenzamide

2-Bromoacetyl bromide

4-hydroxybenzotrifluoride

Downstream raw materials:

5-(2-(pyrrolidin-1-yl)acetamido)-2-(4-(trifluoromethyl)phenoxy)-N-butylbenzamide

5-(2-(piperidin-1-yl)acetamido)-2-(4-(trifluoromethyl)phenoxy)-N-butylbenzamide