4-Hydroxy-1-oxo-1,2-dihydro-1λ⁴-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide

Base Information

• Chemical Name: 4-Hydroxy-1-oxo-1,2-dihydro-1λ⁴-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide
• CAS No.: 188423-48-5
• Molecular Formula: C₁₆H₁₂ClNO₃S
• Molecular Weight: 333.795

Synonyms:4-Hydroxy-1-oxo-1,2-dihydro-1λ⁴-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide

Chemical Property of 4-Hydroxy-1-oxo-1,2-dihydro-1λ⁴-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide

Chemical Property:

Purity/Quality:

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Technology Process of 4-Hydroxy-1-oxo-1,2-dihydro-1λ⁴-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide

There total 3 articles about 4-Hydroxy-1-oxo-1,2-dihydro-1λ⁴-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Hydroxy-2H-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide (188423-47-4) → 4-Hydroxy-1-oxo-1,2-dihydro-1λ4-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide (188423-48-5)

Guidance literature:

With Oxone; In water; acetone; at 0 - 20 ℃; for 1h;

DOI:10.1021/jm9607010

Reference yield:

2,3-dihydro-4H-[1]benzothiopyran-4-one (3528-17-4) → 4-Hydroxy-1-oxo-1,2-dihydro-1λ4-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide (188423-48-5)

Guidance literature:

Multi-step reaction with 3 steps

1: TiCl₄ / toluene; petroleum ether / Ambient temperature

2: 2.) 2N aq. HCl / 1.) CHCl₃, reflux, 2.5 h, 2.) CHCl₃, reflux, 15 min

3: oxone / acetone; H₂O / 1 h / 0 - 20 °C

With hydrogenchloride; Oxone; titanium tetrachloride; In water; acetone; toluene; Petroleum ether;

DOI:10.1021/jm9607010

Reference yield:

4-(1-pyrrolidinyl)-2H-thiochromene (67220-30-8) → 4-Hydroxy-1-oxo-1,2-dihydro-1λ4-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide (188423-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) 2N aq. HCl / 1.) CHCl₃, reflux, 2.5 h, 2.) CHCl₃, reflux, 15 min

2: oxone / acetone; H₂O / 1 h / 0 - 20 °C

With hydrogenchloride; Oxone; In water; acetone;

DOI:10.1021/jm9607010

upstream raw materials:

4-Hydroxy-2H-thiochromene-3-carboxylic acid (3-chloro-phenyl)-amide

2,3-dihydro-4H-[1]benzothiopyran-4-one

4-(1-pyrrolidinyl)-2H-thiochromene

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