thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester

Base Information

• Chemical Name: thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester
• CAS No.: 433692-84-3
• Molecular Formula: C₁₆H₂₂ClO₄PS
• Molecular Weight: 376.841
• Mol file: 433692-84-3.mol

Synonyms:thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester

Chemical Property of thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester

There total 2 articles about thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1-(4-chlorophenyl)-4-methylpent-1-en-3-one (67962-15-6) → thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester (433692-84-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI; Et₃N / acetonitrile / 20 - 70 °C

2: CH₂Cl₂ / -78 - 20 °C

With triethylamine; sodium iodide; In dichloromethane; acetonitrile;

DOI:10.1016/S0022-328X(01)01275-X

Reference yield:

diethoxyoxophosphoranesulfenyl chloride (1186-08-9) + {1-[(E)-2-(4-Chloro-phenyl)-vinyl]-2-methyl-propenyloxy}-trimethyl-silane → thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester (433692-84-3)

Guidance literature:

In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/S0022-328X(01)01275-X

Reference yield: 56.0%

trimethylsilylacetylene (1066-54-2) + thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester (433692-84-3) → {3-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-pent-3-en-1-ynyl}-trimethyl-silane

Guidance literature:

trimethylsilylacetylene; With sodium amide; In tetrahydrofuran; at 20 ℃;

thiophosphoric acid S-[4-(4-chloro-phenyl)-1,1-dimethyl-2-oxo-but-3-enyl] ester O,O'-diethyl ester; In tetrahydrofuran; for 0.166667h;

DOI:10.1016/S0022-328X(01)01275-X

upstream raw materials:

diethoxyoxophosphoranesulfenyl chloride

(E)-1-(4-chlorophenyl)-4-methylpent-1-en-3-one