6-(2-morpholin-4-ylethoxy)-2-thieno[3,2-c]pyridin-6-ylchromen-4-one oxime hydrochloride

Base Information

• Chemical Name: 6-(2-morpholin-4-ylethoxy)-2-thieno[3,2-c]pyridin-6-ylchromen-4-one oxime hydrochloride
• CAS No.: 1300033-36-6
• Molecular Formula: C₂₂H₂₁N₃O₄S*ClH
• Molecular Weight: 459.953
• Mol file: 1300033-36-6.mol

Synonyms:6-(2-morpholin-4-ylethoxy)-2-thieno[3,2-c]pyridin-6-ylchromen-4-one oxime hydrochloride

Chemical Property of 6-(2-morpholin-4-ylethoxy)-2-thieno[3,2-c]pyridin-6-ylchromen-4-one oxime hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2-morpholin-4-ylethoxy)-2-thieno[3,2-c]pyridin-6-ylchromen-4-one oxime hydrochloride

There total 1 articles about 6-(2-morpholin-4-ylethoxy)-2-thieno[3,2-c]pyridin-6-ylchromen-4-one oxime hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thieno[3,2-c]pyridine-6-carboxylic acid methyl ester (253332-82-0) → 6-(2-morpholin-4-ylethoxy)-2-thieno[3,2-c]pyridin-6-ylchromen-4-one oxime hydrochloride (1300033-36-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine; sodium hydride / mineral oil / 1 h / 90 °C

1.2: 1 h / 110 °C

2.1: ethanol / 12 h / 120 °C / Sealed tube

3.1: potassium hydroxide; tert-butyl XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; 1,4-dioxane / 12 h / 100 °C / Sealed tube; Inert atmosphere

4.1: potassium carbonate / acetonitrile / 16 h / Reflux

5.1: titanium tetrachloride / dichloromethane / 26 h / 0 - 20 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; titanium tetrachloride; sodium hydride; potassium carbonate; potassium hydroxide; tert-butyl XPhos; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile; mineral oil; 3.1: |Buchwald-Hartwig Coupling;

DOI:10.1021/acs.jmedchem.7b00991

upstream raw materials:

thieno[3,2-c]pyridine-6-carboxylic acid methyl ester