ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate

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Chemical Name:ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate
CAS No.:1393127-04-2
Molecular Formula:C₂₆H₂₉F₃N₄O₃
Molecular Weight:502.536
Hs Code.:

Synonyms:ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate

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Chemical Property of ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate

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Technology Process of ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate

There total 7 articles about ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1393127-01-9
4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzoic acid

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1393127-04-2
ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

: 1393125-57-9
4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]aniline

: 1393127-04-2
ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: nido-decaborane / methanol / 0 °C

2: lithium hydroxide; water / methanol

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / tetrahydrofuran

With nido-decaborane; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2013.03.014

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1393127-04-2
ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 80 °C

2: palladium 10% on activated carbon; ammonium formate / ethanol; tetrahydrofuran

3: nido-decaborane / methanol / 0 °C

4: lithium hydroxide; water / methanol

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / tetrahydrofuran

With nido-decaborane; palladium 10% on activated carbon; water; ammonium formate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2013.03.014