(S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid benzyl ester

Base Information

Chemical Name:(S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid benzyl ester
CAS No.:617699-49-7
Molecular Formula:C₂₄H₂₉NO₆
Molecular Weight:427.497
Hs Code.:

Synonyms:(S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid benzyl ester

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Chemical Property of (S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid benzyl ester

Chemical Property:

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Technology Process of (S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid benzyl ester

There total 5 articles about (S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

: 617699-47-5
(S)-1,2,3,4-tetrahydro-6,7-dihydroxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid

: 100-44-7
benzyl chloride

: 617699-49-7
(S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid benzyl ester

Guidance literature:: With potassium carbonate; tetrabutylammomium bromide; sodium iodide; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 5h;

Reference yield: 93.8%

: 358627-67-5
(S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid

: 100-44-7
benzyl chloride

: 617699-49-7
(S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid benzyl ester

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 - 50 ℃; for 5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 617699-49-7
(S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-(tert-butyloxycarbonyl)-3-isoquinolinecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / water / 0 - 5 °C

1.2: 16 h / 0 - 25 °C

1.3: 5 - 15 °C

2.1: sodium hydroxide / water; acetone / 1 h / 20 - 65 °C

2.2: 1 h / 0 - 15 °C

3.1: tetrabutylammomium bromide; potassium carbonate / DMF (N,N-dimethyl-formamide) / 5 h / 20 - 50 °C

With sodium hydroxide; tetrabutylammomium bromide; potassium carbonate; triethylamine; In DMF (N,N-dimethyl-formamide); water; acetone;