N⁶-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine

Base Information

• Chemical Name: N⁶-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine
• CAS No.: 1247023-19-3
• Molecular Formula: C₃₁H₄₆N₆O₆Si₂
• Molecular Weight: 654.914

Synonyms:N⁶-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine

Chemical Property of N⁶-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine

Chemical Property:

Purity/Quality:

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Technology Process of N⁶-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine

There total 8 articles about N⁶-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N6-benzoyladenine (4005-49-6) + 1-[3',5'-O-tetraisopropyldisiloxane-2'-O,4'-C-(N-methylaminomethylene)-β-D-ribofuranosyl]-5-methyl-4-(1,2,4-triazol-1-yl)pyrimidin-2-one (1247023-26-2) → N6-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine (1247023-19-3)

Guidance literature:

N₆-benzoyladenine; 1-[3',5'-O-tetraisopropyldisiloxane-2'-O,4'-C-(N-methylaminomethylene)-β-D-ribofuranosyl]-5-methyl-4-(1,2,4-triazol-1-yl)pyrimidin-2-one; With N,O-bis-(trimethylsilyl)-acetamide; In toluene; Reflux;

With trimethylsilyl trifluoromethanesulfonate; In toluene; for 0.5h; Reflux;

Reference yield: 79.4%

N6-benzoyladenine (4005-49-6) + N4-acetyl-3',5'-O-(tetraisopropyldisiloxane)-5-methyl-2'-O,4'-C-(N-methylaminomethylene)cytidine (1247023-16-0) → N6-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine (1247023-19-3)

Guidance literature:

N₆-benzoyladenine; N⁴-acetyl-3',5'-O-(tetraisopropyldisiloxane)-5-methyl-2'-O,4'-C-(N-methylaminomethylene)cytidine; With N,O-bis-(trimethylsilyl)-acetamide; In toluene; at 80 - 85 ℃; for 0.666667h;

With trimethylsilyl trifluoromethanesulfonate; In toluene; for 0.5h; Product distribution / selectivity;

Reference yield: 72.0%

N6-benzoyladenine (4005-49-6) + 3-N-benzoyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-4-methyl-2'-O,4'-C-(N-methylaminomethylene)uridine (1247023-20-6) → N6-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine (1247023-19-3)

Guidance literature:

N₆-benzoyladenine; 3-N-benzoyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-4-methyl-2'-O,4'-C-(N-methylaminomethylene)uridine; With N,O-bis-(trimethylsilyl)-acetamide; In toluene; for 1h; Reflux;

With trimethylsilyl trifluoromethanesulfonate; In toluene; for 4.5h; Reflux;

upstream raw materials:

N₆-benzoyladenine

1-[3',5'-O-tetraisopropyldisiloxane-2'-O,4'-C-(N-methylaminomethylene)-β-D-ribofuranosyl]-5-methyl-4-(1,2,4-triazol-1-yl)pyrimidin-2-one

3-N-benzoyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-4-methyl-2'-O,4'-C-(N-methylaminomethylene)uridine

3',5'-O-tetraisopropyldisiloxane-5-methyl-2'-O,4'-C-(N-methylaminomethylene)cytidine

Downstream raw materials:

6-N-benzoyl-2'-O,4'-C-(N-methylaminomethylene)adenosine

N⁶-benzoyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)adenosine

N⁶-benzoyl-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)adenosine

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