8-bromo-2-[5-(4-methoxy-2,6-dimethylphenyl)-pyridin-2-yl]-1,10-phenanthroline

Base Information

Chemical Name:8-bromo-2-[5-(4-methoxy-2,6-dimethylphenyl)-pyridin-2-yl]-1,10-phenanthroline
CAS No.:338989-84-7
Molecular Formula:C₂₆H₂₀BrN₃O
Molecular Weight:470.368
Hs Code.:

Synonyms:8-bromo-2-[5-(4-methoxy-2,6-dimethylphenyl)-pyridin-2-yl]-1,10-phenanthroline

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Chemical Property of 8-bromo-2-[5-(4-methoxy-2,6-dimethylphenyl)-pyridin-2-yl]-1,10-phenanthroline

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Technology Process of 8-bromo-2-[5-(4-methoxy-2,6-dimethylphenyl)-pyridin-2-yl]-1,10-phenanthroline

There total 3 articles about 8-bromo-2-[5-(4-methoxy-2,6-dimethylphenyl)-pyridin-2-yl]-1,10-phenanthroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 207461-12-9
3-bromo-9-iodo-1,10-phenanthroline

: 338989-69-8
2-bromo-5-(4-dimethoxy-2,6-dimethylphenyl)pyridine

: 338989-84-7
8-bromo-2-[5-(4-methoxy-2,6-dimethylphenyl)-pyridin-2-yl]-1,10-phenanthroline

Guidance literature:: 2-bromo-5-(4-dimethoxy-2,6-dimethylphenyl)pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

With zinc(II) chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃;

3-bromo-9-iodo-1,10-phenanthroline; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; for 12h; Heating;
DOI:10.1002/1521-3773(20010216)40:4<754::AID-ANIE7540>3.0.CO;2-T

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 338989-84-7
8-bromo-2-[5-(4-methoxy-2,6-dimethylphenyl)-pyridin-2-yl]-1,10-phenanthroline

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiR

1.2: iodine

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: zinc chloride / tetrahydrofuran; hexane / -78 - 20 °C

2.3: 85 percent / [Pd(PPh₃)4] / tetrahydrofuran; hexane / 12 h / Heating

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

3.2: zinc chloride / tetrahydrofuran; hexane / -78 - 20 °C

3.3: 77 percent / [Pd(PPh₃)4] / tetrahydrofuran; hexane / 12 h / Heating

With n-butyllithium; In tetrahydrofuran; hexane; 2.3: Negishi coupling / 3.3: Negishi coupling;
DOI:10.1002/1521-3773(20010216)40:4<754::AID-ANIE7540>3.0.CO;2-T

Reference yield:

: 73290-22-9
2-bromo-5-iodo-pyridine

: 338989-84-7
8-bromo-2-[5-(4-methoxy-2,6-dimethylphenyl)-pyridin-2-yl]-1,10-phenanthroline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

1.2: zinc chloride / tetrahydrofuran; hexane / -78 - 20 °C

1.3: 85 percent / [Pd(PPh₃)4] / tetrahydrofuran; hexane / 12 h / Heating

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: zinc chloride / tetrahydrofuran; hexane / -78 - 20 °C

2.3: 77 percent / [Pd(PPh₃)4] / tetrahydrofuran; hexane / 12 h / Heating

With n-butyllithium; In tetrahydrofuran; hexane; 1.3: Negishi coupling / 2.3: Negishi coupling;
DOI:10.1002/1521-3773(20010216)40:4<754::AID-ANIE7540>3.0.CO;2-T