N-{7-benzyl-4-methyl-5-[(2,4,5-trimethoxyphenyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

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Chemical Name:N-{7-benzyl-4-methyl-5-[(2,4,5-trimethoxyphenyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide
CAS No.:1321914-01-5
Molecular Formula:C₃₅H₄₀N₄O₅
Molecular Weight:596.726
Hs Code.:

Synonyms:N-{7-benzyl-4-methyl-5-[(2,4,5-trimethoxyphenyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

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Chemical Property of N-{7-benzyl-4-methyl-5-[(2,4,5-trimethoxyphenyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

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Technology Process of N-{7-benzyl-4-methyl-5-[(2,4,5-trimethoxyphenyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

There total 4 articles about N-{7-benzyl-4-methyl-5-[(2,4,5-trimethoxyphenyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 101911-62-0
2,4,5-trimethoxyphenylacetylene

: 306315-01-5
2,2-dipivaloylamino-4-methyl-5-iodo-7-(N-benzyl)pyrrolo[2,3-d]pyrimidine

: 1321914-01-5
N-{7-benzyl-4-methyl-5-[(2,4,5-trimethoxyphenyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In 1,1-dichloroethane; at 20 ℃; for 24h; Inert atmosphere; Darkness;
DOI:10.1016/j.bmc.2011.05.030

Reference yield:

: 1321914-20-8
(2,4,5-trimethoxyphenylethynyl)trimethylsilane

: 1321914-01-5
N-{7-benzyl-4-methyl-5-[(2,4,5-trimethoxyphenyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 1,1-dichloroethane / 24 h / 20 °C / Inert atmosphere; Darkness

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1,1-dichloroethane; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.030

Reference yield:

: 135-77-3
1,2,4-trimethoxy-benzene

: 1321914-01-5
N-{7-benzyl-4-methyl-5-[(2,4,5-trimethoxyphenyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; acetic acid / 0.17 h / 0 °C

2: copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine / 1,4-dioxane / 20 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 1,1-dichloroethane / 24 h / 20 °C / Inert atmosphere; Darkness

With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; bromine; acetic acid; triethylamine; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 1,1-dichloroethane; 2: Sonogashira coupling / 4: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.030