2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile

Base Information

• Chemical Name: 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile
• CAS No.: 243665-84-1
• Molecular Formula: C₁₈H₁₃ClFN₃O
• Molecular Weight: 341.772

Synonyms:2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile

Chemical Property of 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile

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Technology Process of 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile

There total 1 articles about 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-chloro-4-fluorophenylamine (367-21-5) + 2-bromo-1-(p-methoxyphenyl)ethylidenemalononitrile (75562-68-4) → 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile (243665-84-1)

Guidance literature:

In isopropyl alcohol; at 60 - 65 ℃; for 1h;

DOI:10.1002/jhet.5570360325

Reference yield: 75.0%

orthoformic acid triethyl ester (122-51-0) + 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile (243665-84-1) → 1-(3-chloro-4-fluorophenyl)-N-ethoxymethylene-2-amino-3-cyano-4-(4-methoxyphenyl)pyrrole (1006628-53-0)

Guidance literature:

Heating;

DOI:10.1002/hc.20295

Reference yield: 72.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile (243665-84-1) → 4-amino-7-(3-chloro-4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (243665-90-9)

Guidance literature:

With formic acid; In N,N-dimethyl-formamide; Heating;

DOI:10.1002/jhet.5570360325

upstream raw materials:

3-chloro-4-fluorophenylamine

2-bromo-1-(p-methoxyphenyl)ethylidenemalononitrile

Downstream raw materials:

7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

4-amino-7-(3-chloro-4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine

1-(3-chloro-4-fluorophenyl)-N-ethoxymethylene-2-amino-3-cyano-4-(4-methoxyphenyl)pyrrole

3-amino-4-imino-5-(4-methoxyphenyl)-7-(3-chloro-4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine

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