Technology Process of 5-<(3-carboxyphenyl)sulfonyl>-2-<(6-phenylhexyl)oxy>benzenepropanoic acid
There total 7 articles about 5-<(3-carboxyphenyl)sulfonyl>-2-<(6-phenylhexyl)oxy>benzenepropanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol; water;
at 25 ℃;
for 4h;
Yield given;
DOI:10.1021/jm00172a019
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 68 percent / sulfuric acid / 96 h / Heating
2: 100 percent / pivalic acid / toluene / Heating
3: 86 percent / 1 N HCl, ethanol / 0.5 h / 25 °C
4: 1.) NaH / 1.) DMF, 25 deg C, 30 min, 2.) 65 deg C, overnight
5: m-chloroperoxybenzoic acid (mPCBA) / CH2Cl2 / 2 h / 0 °C
6: KOH / methanol; H2O / 4 h / 25 °C
With
hydrogenchloride; potassium hydroxide; ethanol; sulfuric acid; sodium hydride; 3-chloro-benzenecarboperoxoic acid; Trimethylacetic acid;
In
methanol; dichloromethane; water; toluene;
DOI:10.1021/jm00172a019
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 85 percent / pyridine hydrochloride / 4 h / 180 °C
2: 68 percent / sulfuric acid / 96 h / Heating
3: 100 percent / pivalic acid / toluene / Heating
4: 86 percent / 1 N HCl, ethanol / 0.5 h / 25 °C
5: 1.) NaH / 1.) DMF, 25 deg C, 30 min, 2.) 65 deg C, overnight
6: m-chloroperoxybenzoic acid (mPCBA) / CH2Cl2 / 2 h / 0 °C
7: KOH / methanol; H2O / 4 h / 25 °C
With
hydrogenchloride; potassium hydroxide; ethanol; sulfuric acid; pyridine hydrochloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; Trimethylacetic acid;
In
methanol; dichloromethane; water; toluene;
DOI:10.1021/jm00172a019