4-methyoxybenzyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate

Base Information

• Chemical Name: 4-methyoxybenzyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate
• CAS No.: 1610054-74-4
• Molecular Formula: C₁₇H₁₅BrN₂O₄
• Molecular Weight: 391.221
• Mol file: 1610054-74-4.mol

Synonyms:4-methyoxybenzyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate

Chemical Property of 4-methyoxybenzyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-methyoxybenzyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate

There total 2 articles about 4-methyoxybenzyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H17BrO4 (1610055-11-2) → 4-methyoxybenzyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate (1610054-74-4)

Guidance literature:

With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol5011505

Reference yield:

2-(2-bromo-5-methoxyphenyl)acetic acid (86826-93-9) + p-Methoxybenzyl bromide (2746-25-0) → 4-methyoxybenzyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate (1610054-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux; Inert atmosphere

2: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C / Inert atmosphere

With 4-acetamidobenzenesulfonyl azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetone; acetonitrile;

DOI:10.1021/ol5011505

Reference yield: 50.0%

4-methyoxybenzyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate (1610054-74-4) → (Z)-1-bromo-4-methoxy-2-(4-methoxystyryl)benzene (1610055-00-9)

Guidance literature:

With tetrakis[(S)-(N-tetrachlorophthalimido)-tert-lucinato]dirhodium(II); In dichloromethane; at 40 ℃; for 5h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol5011505

upstream raw materials:

2-(2-bromo-5-methoxyphenyl)acetic acid

p-Methoxybenzyl bromide

C₁₇H₁₇BrO₄

Downstream raw materials:

(Z)-1-bromo-4-methoxy-2-(4-methoxystyryl)benzene